P300 amplitude during a monetary incentive delay task predicts future therapy completion in individuals with major depressive disorder

White, Evan J.; Nacke, Mariah; Akeman, Elisabeth; Cannon, Mallory J.; Mayeli, Ahmad; Touthang, James; McDermott, Timothy J.; Kirlić, Namik; Santiago, Jessica; Kuplicki, Rayus; Bodurka, Jerzy; Paulus, Martin P.; Craske, Michelle G.; Wolitzky-Taylor, Kate; Abelson, James L.; Martell, Christopher R.; Clausen, Ashley; Stewart, Jennifer L.; Aupperle, Robin L.

doi:10.1016/j.jad.2021.08.106

Cited by 13 publications

(15 citation statements)

References 55 publications

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“…These results were in some ways consistent with many previous studies using fMRI and event-related potentials that reported blunted striatal reactivity to reward in depression. [55][56][57][58] They were also consistent with a more limited number of studies that reported similar findings for people with anxiety disorders. 9,59,60 However, given the complementary role of the striatum in updating behavioural strategies by incorporating new information, 61,62 a weaker link between the brain and behaviour during affective outcomes for participants with anxiety or depression (compared to healthy participants) could indicate that these people were less effective in updating their behavioural strategy based on emotionally salient information.…”

Section: Discussionsupporting

confidence: 88%

Striatal reactivity during emotion and reward relates to approach–avoidance conflict behaviour and is altered in adults with anxiety or depression

McDermott

Berg

Touthang

et al. 2022

jpn

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Background:We have previously reported activation in reward, salience and executive control regions during functional MRI (fMRI) using an approach-avoidance conflict (AAC) decision-making task with healthy adults. Further investigations into how anxiety and depressive disorders relate to differences in neural responses during AAC can inform their understanding and treatment. We tested the hypothesis that people with anxiety or depression have altered neural activation during AAC. Methods: We compared 118 treatment-seeking adults with anxiety or depression and 58 healthy adults using linear mixed-effects models to examine group-level differences in neural activation (fMRI) during AAC decision-making. Correlational analyses examined relationships between behavioural and neural measures. Results: Adults with anxiety or depression had greater striatal engagement when reacting to affective stimuli (p = 0.008, d = 0.31) regardless of valence, and weaker striatal engagement during reward feedback (p = 0.046, d = −0.27) regardless of the presence of monetary reward. They also had blunted amygdala activity during decision-making (p = 0.023, d = −0.32) regardless of the presence of conflict. Across groups, approach behaviour during conflict decision-making was inversely correlated with striatal activation during affective stimuli (p < 0.001, r = −0.28) and positively related to striatal activation during reward feedback (p < 0.001, r = 0.27). Limitations: Our transdiagnostic approach did not allow for comparisons between specific anxiety disorders, and our cross-sectional approach did not allow for causal inference. Conclusion: Anxiety and depression were associated with altered neural responses to AAC. Findings were consistent with the role of the striatum in action selection and reward responsivity, and they point toward striatal reactivity as a future treatment target. Blunting of amygdala activity in anxiety or depression may indicate a compensatory response to inhibit affective salience and maintain approach.

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Section: Discussionsupporting

confidence: 88%

Striatal reactivity during emotion and reward relates to approach–avoidance conflict behaviour and is altered in adults with anxiety or depression

McDermott

Berg

Touthang

et al. 2022

jpn

Self Cite

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“…To the extent that fb-P3 is related to a common oddball P3b (e.g., Polich, 2007) or the late positive potential to arousing stimuli (e.g., Olofsson et al, 2008), both considered an index of motivated attention (e.g., Bradley, 2009;Kayser et al, 2017;Vuilleumier & Driver, 2007), its reduction in depression is consistent with prior findings (e.g., Bruder, Kayser & Tenke, 2012;Kayser et al, 2000). In a study using clinical trial data employing certain forms of behavior therapy (White et al, 2021), fb-P3 amplitude was an indicator of treatment completion outcome: individuals who completed the treatment had a reduced fb-P3 amplitude before treatment than those who did not complete treatment. fb-P3 was further found to be more reduced in response to like/dislike media feedback (thumbs-up or -down picture) than monetary win or loss, suggesting greater attention allocation to social than monetary feedback (Ait Oumeziane et al, 2019;Zhang et al, 2020).…”

Section: Introductionsupporting

confidence: 80%

“…Blunted fb-P3 was also suggested to be associated with reduced allocation of attention to uncertainty in monetary trials. With regard to depression, studies have found fb-P3 to be inversely related to depressive symptoms in trials offering a chance of monetary gains, suggesting deficient motivational salience for these reward stimuli (Ait Oumeziane et al, 2019;Chang et al, 2020;White et al, 2021;Zhang et al, 2020). To the extent that fb-P3 is related to a common oddball P3b (e.g., Polich, 2007) or the late positive potential to arousing stimuli (e.g., Olofsson et al, 2008), both considered an index of motivated attention (e.g., Bradley, 2009;Kayser et al, 2017;Vuilleumier & Driver, 2007), its reduction in depression is consistent with prior findings (e.g., Bruder, Kayser & Tenke, 2012;Kayser et al, 2000).…”

Section: Introductionmentioning

confidence: 99%

Feedback negativity and feedback-related P3 in individuals at risk for depression: Comparing surface potentials and current source densities

Gao¹,

Wong²,

Gameroff³

et al. 2022

Preprint

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Our findings add nuanced ERP evidence of altered reward processing in depression and depression risk. Whereas robust condition effects (win, loss, neutral feedback) were congruent with prior research, our comparative side-by-side analysis of ERPs and their current source density transformations using permutation tests and multilevel modeling revealed that the characterization of subtle group differences is impeded and potentially altered by the EEG reference choice, underscoring the importance of using reference-free techniques for analyzing ERPs.

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“…Variations in the reward cue‐P300, CNV, and SPN have all been associated with reward‐related mental health concerns, including blunted anticipatory activity related to depression (Ait Oumeziane et al, 2019; Landes et al, 2018; Luking et al, 2021; Zhang et al, 2020), history of suicide attempts (Tsypes et al, 2021), and ADHD (Kaiser et al, 2020), but amplified anticipatory activity related to substance use disorder (Morie et al, 2016; though see Zhao et al, 2017). These anticipatory components have also been shown to predict therapy compliance, further supporting their clinical utility (White et al, 2021). Importantly, the cue‐P300, CNV, and SPN appear to differentiate distinct aspects of dysfunctional reward anticipation (Bennett et al, 2019; Novak et al, 2016).…”

Section: Introductionmentioning

confidence: 82%

The potential application of event‐related potentials to enhance research on reward processes in eating disorders

Forester

Schaefer

Dodd

et al. 2022

Intl J Eating Disorders

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Objective Reward‐related processes have been posited as key mechanisms underlying the onset and persistence of eating disorders, prompting a growing body of research in this area. Existing studies have primarily utilized self‐report, behavioral, and functional magnetic resonance imaging measures to interrogate reward among individuals with eating disorders. However, limitations inherent in each of these methods (e.g., poor temporal resolution) may obscure distinct neurocognitive reward processes, potentially contributing to underdeveloped models of reward dysfunction within eating disorders. The temporal precision of event‐related potentials (ERPs), derived from electroencephalography, may thus offer a powerful complementary tool for elucidating the neurocognitive underpinnings of reward. Indeed, a considerable amount of research in other domains of psychopathology (e.g., depression, substance use disorders), as well as studies investigating food reward among non‐clinical samples, highlights the utility of ERPs for probing reward processes. However, no study to date has utilized ERPs to directly examine reward functioning in eating disorders. Methods In this paper, we review evidence underscoring the clinical utility of ERP measures of reward, as well as a variety of reward‐related tasks that can be used to elicit specific ERP components with demonstrated relevance to reward processing. We then consider the ways in which these tasks/components may be used to help answer a variety of open questions within the eating disorders literature on reward. Results/Discussion Given the promise of ERP measures of reward to the field of eating disorders, we ultimately hope to spur and guide research in this currently neglected area. Public Significance Abnormalities in reward functioning appear to contribute to eating disorders. Event‐related potentials (ERPs) offer temporally precise measures of neurocognitive reward processing and thus may be important tools for understanding the relationship between reward and disordered eating. However, research in this area is currently lacking. This paper attempts to facilitate the use of ERPs to study reward among individuals with eating disorders by reviewing the relevant theories and methods.

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P300 amplitude during a monetary incentive delay task predicts future therapy completion in individuals with major depressive disorder

Cited by 13 publications

References 55 publications

Striatal reactivity during emotion and reward relates to approach–avoidance conflict behaviour and is altered in adults with anxiety or depression

Striatal reactivity during emotion and reward relates to approach–avoidance conflict behaviour and is altered in adults with anxiety or depression

Feedback negativity and feedback-related P3 in individuals at risk for depression: Comparing surface potentials and current source densities

The potential application of event‐related potentials to enhance research on reward processes in eating disorders

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