P30 PAI-1 4G/5G polymorphism detection and obstetric complications

The association between thrombophilic gene mutations and recurrent pregnancy loss

“…Contradictory of the recent study by Subrt et al [38] that demonstrated a strong positive association between PAI-1 and ACE mutations and pregnancy loss [38], in our study and other authors, no relationship was founded between the presence of ACE and PAI-1 mutant alleles and RPL [8,15,21,22]…”

Analysis of Plasminogen Activator Inhibitor‐1, Integrin Beta3, Beta Fibrinogen, and Methylenetetrahydrofolate Reductase Polymorphisms in Iranian Women with Recurrent Pregnancy Loss

“…Sun et al 26 confirmed that homozygosity for PAI-1 4G polymorphisms is significantly higher in patients with RPL, which may result in increased PAI-1 concentrations and hypofibrinolysis and contribute to early pregnancy loss. Gumpel et al 29 did not find any association between this polymorphism and early or late pregnancy loss. Thus, they suggested that the 4G variant of the PAI-1 gene may predispose a subset of celiac women to pregnancy loss.…”

Association between plasminogen activator inhibitor 1 gene mutation and different subgroups of recurrent miscarriage and implantation failure

“…Butchholz et al (2003) reported a tendency towards the presence of higher frequencies of 4G/4G carriers among patients with a history of two or more consecutive unexplained spontaneous miscarriages (39.1 %) compared to controls (32.3 %), but the difference was not significant (P =0.22) [1]. In addition, no association between this polymorphism and early or late pregnancy loss was observed by Gumpel et al [24].…”