P3 reduction in auditory evoked potentials of schizophrenics

Roth, Walton T.; Pfefferbaum, Adolf; Horvath, Thomas; Berger, Philip A.; Kopell, Bert S.

doi:10.1016/0013-4694(80)90392-2

Cited by 130 publications

(42 citation statements)

References 17 publications

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“…Abnormalities in P300 may reflect deficits in cognitive updating, information processing, and selective attention. [4][5][6] The P300 reduction in schizophrenia cannot be attributed to latency variability on individual trials or to absence of P300 on a subset of target trials, [7][8][9] and persists even when clinical improvement is observed. 8,10,11 Patients with schizophrenia also show regional P300 amplitude reduction over the left temporal region.…”

Section: Discussionmentioning

confidence: 99%

Association Between Smaller Left Posterior Superior Temporal Gyrus Volume on Magnetic Resonance Imaging and Smaller Left Temporal P300 Amplitude in First-Episode Schizophrenia

McCarley¹,

Salisbury²,

Hirayasu³

et al. 2002

Arch Gen Psychiatry

171

113

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Background:In chronic schizophrenia, the P300 is broadly reduced and shows a localized left temporal deficit specifically associated with reduced gray matter volume of the left posterior superior temporal gyrus (STG). In first-episode patients, a similar left temporal P300 deficit is present in schizophrenia, but not in affective psychosis. The present study investigated whether the left temporal P300-left posterior STG volume association is selectively present in first-episode schizophrenia.

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Section: Discussionmentioning

confidence: 99%

Association Between Smaller Left Posterior Superior Temporal Gyrus Volume on Magnetic Resonance Imaging and Smaller Left Temporal P300 Amplitude in First-Episode Schizophrenia

McCarley¹,

Salisbury²,

Hirayasu³

et al. 2002

Arch Gen Psychiatry

171

113

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“…Application of ERP paradigms to schizophrenia has revealed marked abnormalities (Levit, Sutton, & Zubin, 1973;Roth, Pfefferbaum, Horvath, Berger, & Kopell, 1980). In the initial period of investigation, the P300 component of the ERP recorded at midline electrode sites was most intensively studied ( Figure 1).…”

Section: P300 Component In Schizophreniamentioning

confidence: 99%

“…Reduction of P300 amplitude to target stimuli has been found across laboratories (reviewed by Bruder et al, 1996;McCarley, Faux, Shenton, Nestor, &Adams, 1991), although more reliably for auditory than visual stimuli (Ford et al, 1994a). Although auditory P300 latency prolongation sometimes has been reported in schizophrenia, P300 amplitude reduction is not due to increased latency variability in the patients (Ford, White, Lim, & Pfefferbaum, 1994b;Roth et al, 1980). Auditory P300 amplitude reduction has been shown in patients receiving medication (Faux et al, 1990;Pfefferbaum, Ford, White, & Roth, 1989), patients withdrawn from medication Ford et al, 1994a;Pfefferbaum et al, 1989), and patients in the first episode of the illness (Salisbury et al, 1998) and in nevermedicated patients .…”

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confidence: 96%

“…If schizophrenia entails a component with a disorder of neural circuits, then the measurement of electrical currents produced by activity in these circuits should provide an important method to investigate the disorder. In particular, electrical activity reflecting attention, working memory, and categorization, faculties frequently disrupted in the illness, would be expected to be abnormal (Bleuler, 1911(Bleuler, /1950Chapman & Chapman, 1973;Neale & Oltmanns, 1980;.Application of ERP paradigms to schizophrenia has revealed marked abnormalities (Levit, Sutton, & Zubin, 1973;Roth, Pfefferbaum, Horvath, Berger, & Kopell, 1980). In the initial period of investigation, the P300 component of the ERP recorded at midline electrode sites was most intensively studied ( Figure 1).…”

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Identification of neural circuits underlying P300 abnormalities in schizophrenia

et al. 1999

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Event-related potentials (ERPs) provide a noninvasive method to evaluate neural activation and cognitive processes in schizophrenia. The pathophysiological significance of these findings would be greatly enhanced if scalp-recorded ERP abnormalities could be related to specific neural circuits and/or regions of the brain. Using quantitative approaches in which scalp-recorded ERP components are correlated with underlying neuroanatomy in schizophrenia, we focused on biophysical and statistical procedures (partial least squares) to relate the auditory P300 component to anatomic measures obtained from quantitative magnetic resonance imaging. These findings are consistent with other evidence that temporal lobe structures contribute to the generation of the scalp-recorded P300 component and that P300 amplitude asymmetry over temporal recording sites on the scalp may reflect anatomic asymmetries in the volume of the superior temporal gyrus in schizophrenia. DescriptorsEvent-related potentials; P300; MRI; Neuroanatomy; Schizophrenia Event-related potential (ERP) techniques have been used in the study of schizophrenia for several decades, but determining the relationship of ERP abnormalities to specific anatomic abnormalities has only recently been undertaken. Here, we survey methods for establishing the relationship of scalp-recorded ERPs and neuroanatomy, focusing on the auditory P300 component. We first review P300 amplitude and topography disturbances in schizophrenia and evidence from a variety of techniques which have indicated an association of the P300 component with temporal lobe structures. We next review biophysical source analysis Copyright © 1999 Society for Psychophysiological Research Address reprint requests to: R.W. McCarley, Psychiatry (116A), Brockton VA Medical Center, 940 Belmont Street, Brockton, MA02401, mccarley@warren.med.harvard.edu; or B. F. O'Donnell, Department of Psychology, University of Indiana, Bloomington, IN 47405, bodonnel@indiana.edu. The SPSS code for the PLS procedure described in this paper is available from the corresponding authors. NIH Public Access Author ManuscriptPsychophysiology. Author manuscript; available in PMC 2010 April 6. Published in final edited form as:Psychophysiology. 1999 May ; 36(3): 388-398. NIH-PA Author ManuscriptNIH-PA Author Manuscript NIH-PA Author Manuscript approaches, with a demonstration of bioelectric modeling of the P300 component on an individual head and brain. We conclude with an application of a recently developed multivariate statistical technique, partial least squares analysis. This technique can be applied to define the relationships among large numbers of structural and electrophysiological measures in the relatively small sample size typical in brain imaging studies. In the example presented here, partial least squares analysis was used to relate volumetric measures of temporal lobe gray matter structures to the P300 and N200 components recorded over a 10-20 montage. P300 Component in SchizophreniaSchizophrenia is a severe behavi...

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“…It is a common finding for schizophrenic subjects that the average P300 amplitude measure is reduced com pared to prestimulus baseline [6][7][8][9][10]. Ward et al [11,12] interpreted this phenomenon as an expression of allusive thinking, since they recognized reduced P300 responses in normal subjects with increased conceptual loosening.…”

Section: Introductionmentioning

confidence: 99%

Spectral Analysis of P300 Generation in Depression and Schizophrenia

Röschke

Fell

1997

Neuropsychobiology

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In the past it was reported in several studies that both depressive and schizophrenic patients exhibit reduced P300 amplitudes compared to healthy controls. In order to elucidate the underlying mechanisms of spectral P300 generation, we analysed P300 responses in depression and schizophrenia by a frequency based approach. Herefore, the amplification (poststimulus/prestimulus) of spectral power in different frequency bands was evaluated for non-target and target epochs. Generally, we found that P300 responses are accompanied by a pronounced frequency amplification in the delta and theta range. For the depressive patients we detected only under target condition a statistically significant reduction of alpha and gamma amplification compared to controls. In contrast to this, we observed a highly significant reduction of delta amplification in schizophrenic patients, under both target and non-target conditions.

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P3 reduction in auditory evoked potentials of schizophrenics

Cited by 130 publications

References 17 publications

Association Between Smaller Left Posterior Superior Temporal Gyrus Volume on Magnetic Resonance Imaging and Smaller Left Temporal P300 Amplitude in First-Episode Schizophrenia

Association Between Smaller Left Posterior Superior Temporal Gyrus Volume on Magnetic Resonance Imaging and Smaller Left Temporal P300 Amplitude in First-Episode Schizophrenia

Identification of neural circuits underlying P300 abnormalities in schizophrenia

Spectral Analysis of P300 Generation in Depression and Schizophrenia

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