P3 latency as a biomarker for the complexity of migraine with aura: Event-related potential study

Abstract

Background This study aimed to compare the P3 component between patients who have migraines with aura and healthy subjects, and to compare different subtypes of migraine with aura relative to the complexity of migraine aura. Methods Average Migraine Aura Complexity Score was calculated for each MwA patient. Visual oddball paradigm was used to elicit the P3 component. P3 amplitudes and latencies elicited from frequent and rare stimuli, as well as from difference wave, were compared with healthy subjects. Subsequently, subtypes of migraine with aura were compared and Average Migraine Aura Complexity Score was used to explore the connection between features of the P3 and complexity of migraine with aura. Results 37 patients who have migraine with aura (16 with simple aura and 21 with complex aura) patients and 28 healthy subjects were studied. Patients who have migraine with aura had significantly prolonged latencies compared to healthy subjects (411 ± 39 ms vs 372 ± 34 ms, p < 0.001) relative to a rare condition. Patients who have complex aura significantly differs from patients who have simple aura (427 ± 34 ms vs 389 ± 35 ms, p = 0.004) and healthy subjects (372 ± 34 ms, p < 0.001) relative to P3 latency in a rare condition and the patients who have complex aura significantly differs from healthy subjects (442 ± 37 ms vs 394 ± 33 ms, p < 0.001) relative to P3 latency in difference wave. P3 latency from rare condition positively correlated with the Average Migraine Aura Complexity Score (p < 0.001). Conclusions Visual oddball paradigm, particularly rare stimuli, could serve as a potential new tool for deep profiling of different clinical complexities among patients who have migraine with aura. Also, the present pattern of P3 components provided new evidence for the cognitive dysfunctions in patients who have migraine with aura.

Editorial: Global excellence in brain-computer interfaces: Europe

“…The preliminary results were comparable to the best reported in the literature, suggesting that AD detection could be automatically achieved through automated processing and commercial EEG systems. This research aligns with recent trends in combining non-invasive electrophysiological recordings with state-of-the-art signal processing and machine learning techniques to discover novel biomarkers for neurological disorders (Petrusic et al, 2022 ; Mitrović et al, 2023 ).…”

Whole brain surface-based morphometry and tract-based spatial statistics in migraine with aura patients: difference between pure visual and complex auras

“…These differences were also highlighted in an evoked potential study where visual pathway activity was greater in complex aura sufferers than in pure visual aura, but both showed a deficient habituation to visual evoked potentials (Coppola et al, 2015). In a recent electrophysiological study, latency of the P3 event-related potential obtained with a visual oddball paradigm was significantly longer in MA+ patients than in MA or HC (Petrusic et al, 2022).…”

Quantitative electroencephalography as a potential biomarker in migraine

“…For instance, Zhu et al (2019) demonstrated the efficacy of somatosensory evoked potentials for migraine classification. Petrusic et al (2022) emphasized the relevance of P3 latency, particularly when understanding the complexity of migraine with aura. Furthermore, another study by Petrusic et al (2021) presented findings on the N400 component in patients experiencing migraines with aura, hinting at the nuances of migraine pathophysiology.…”

“…In addition to the conventional electroencephalography (EEG) methods, various studies have utilized EEG event-related potentials, somatosensory evoked potentials, and visual evoked potentials in the pursuit of potential biomarkers (Hsiao et al, 2023;2021;Petrusic et al, 2021Petrusic et al, , 2022Zhu et al, 2019). For instance, Zhu et al (2019) demonstrated the efficacy of somatosensory evoked potentials for migraine classification.…”

“…Petrusic et al. ( 2022 ) emphasized the relevance of P3 latency, particularly when understanding the complexity of migraine with aura. Furthermore, another study by Petrusic et al.…”