P3‐440: Oxidative stress‐induced mitochondrial failure and brain hypometabolism underlay the pathophysiology of Alzheimer's disease and offer target for treatment: Astonishing effect of melanin and mitochondrial antioxidants

Human photosynthesis, the ultimate answer to the long term mystery of Kleiber’s law or E = M<sup>3/4</sup>: Implication in the context of gerontology and neurodegenerative diseases

“…In addition, this group also showed that rest of the tests no signs of decreases and/or decline below base line for the entire period of the treatment. Our clinical results showed that patients who received integrative treatment with mitochondrial antioxidants, selenium and QIAPI-1 exhibited the most significant cognitive improvement at the end of 36 months of treatment [19][20][21][22]. This study demonstrated that the further examination of the potential pharmacologic modulation of brain hypometabolism by using human photosynthesis compounds such as selective mitochondrial antioxidants and Melanin analogue represents a completely new and more effective strategies to treat Alzheimer and/or other dementia types.…”

“…We have also compared these results with our ongoing clinical study of clinically depressed and/or demented seniors with cardiovascular disease symptoms. Patients receive ALCAR+LA, Omega-3-6-9 from Fish, Flax and Borage Oils, Coenzyme Q-10, and Melanin analogues QIAPI-1, along with a combination of multivitamins and trace elements (selenium) and dietary changes as part of our recently developed brain activation program [19][20][21][22]. The effects of treatment were analyzed by using MMSE and a continuous visual learning task [19][20][21][22].…”

“…Patients that received combination of selective mitochondrial antioxidant plus the Melanin analogue (QIAPI-1) both in combination with our recently developed brain exercising program. Results from this pilot study showed that patients who received the combination of mitochondrial antioxidants and QIAPI-1 presented the maximum significant cognitive improvement at the end of 24 months of treatment [19][20][21][22]. The maximum significant cognitive improvement was seen with the combined treatment in MMSE, attention, memory, naming, construction, clock drawing, verbal fluency, and Ruff Frontal Fluency tests [19][20][21][22].…”

“…Results from this pilot study showed that patients who received the combination of mitochondrial antioxidants and QIAPI-1 presented the maximum significant cognitive improvement at the end of 24 months of treatment [19][20][21][22]. The maximum significant cognitive improvement was seen with the combined treatment in MMSE, attention, memory, naming, construction, clock drawing, verbal fluency, and Ruff Frontal Fluency tests [19][20][21][22]. In addition, this group also showed that rest of the tests no signs of decreases and/or decline below base line for the entire period of the treatment.…”

“…This study demonstrated that the further examination of the potential pharmacologic modulation of brain hypometabolism by using human photosynthesis compounds such as selective mitochondrial antioxidants and Melanin analogue represents a completely new and more effective strategies to treat Alzheimer and/or other dementia types. Therefore, this pilot study demonstrate that further expanding this study to large group of patients able to provide much more accurate and conclusive background regarding new and more effective treatment strategies which based on the brain hypometabolism and neuronal energy crisis theory to fight against for these devastative diseases [19][20][21][22]. Future the perspective of human photosynthesis, that provide one great unifying principle; it is no accident, therefore, that many biological networks exhibit area-preserving branching, even though different anatomical designs exploit different hydrodynamic principles.…”