P3‐238: Age‐associated memory impairment increases risk of conversion to MCI and dementia

Lee, Grace; Elashoff, David; Di, Lijie; Teng, Edmond; Melchor, Stephanie J.; Kim, Johnny; Lu, Po-Haong

doi:10.1016/j.jalz.2012.05.1460

Cited by 2 publications

(3 citation statements)

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“…First, this was a single-centre study that utilised a relatively short treatment duration. It has been suggested that studies examining active interventions in terms of their exerting cognitive benefits should utilise durations as long as 5 years in otherwise healthy adults [ 45 ], whom formed the basis of the present study. It has been recommended therefore that future research might benefit from targeting individuals at risk of enhanced rates of decline [ 45 ], such as those exhibiting age-associated memory impairment in the absence of any underlying pathology [ 45 ].…”

Section: Discussionmentioning

confidence: 99%

“…It has been suggested that studies examining active interventions in terms of their exerting cognitive benefits should utilise durations as long as 5 years in otherwise healthy adults [ 45 ], whom formed the basis of the present study. It has been recommended therefore that future research might benefit from targeting individuals at risk of enhanced rates of decline [ 45 ], such as those exhibiting age-associated memory impairment in the absence of any underlying pathology [ 45 ]. Finding the right balance between conducting heavily controlled trials in healthy adults as opposed to studying those at greater risk, for whom myriad confounding factors are likely to exert influence, is a challenge for future cognitive interventions.…”

Section: Discussionmentioning

confidence: 99%

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The Effects of Vitamin D-Enriched Mushrooms and Vitamin D3 on Cognitive Performance and Mood in Healthy Elderly Adults: A Randomised, Double-Blinded, Placebo-Controlled Trial

et al. 2020

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Despite abundant cross-sectional evidence that low vitamin D status is associated with risk of cognitive decline in ageing, interventional evidence for benefits of vitamin D supplementation is lacking. This study was a 6 month randomised, double-blinded placebo-controlled clinical trial of the effects of vitamin D3 (D3), enhanced vitamin D2 in a mushroom matrix (D2M), standard mushroom (SM) and placebo (PL) on cognition and mood in n = 436 healthy older male (49%) and female volunteers aged ≥ 60 years. Primary end points were change in serum vitamin D metabolites (25-OH-D, 25-OH-D2 and 25-OH-D3), cognitive performance, and mood over 24 weeks. Levels of total 25-OH-D and 25-OH-D3 were maintained in the D3 arm but decreased significantly (p < 0.05) in the remaining arms (D2M, SM and PL). Analysis also revealed differential changes in these metabolites depending on total vitamin D status at baseline. There were no significant effects of treatment on any of the measures of cognitive function or mood. Overall, the results show that daily supplementation of ~600 IU of vitamin D3 was sufficient to maintain 25-OH-D throughout winter months, but in contrast to existing cross-sectional studies there was no support for benefit of vitamin D supplementation for mood or cognition in healthy elderly people.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

The Effects of Vitamin D-Enriched Mushrooms and Vitamin D3 on Cognitive Performance and Mood in Healthy Elderly Adults: A Randomised, Double-Blinded, Placebo-Controlled Trial

et al. 2020

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“…Given the relationships observed herein between changes in B 12 related markers and improved cognitive performance, future studies should consider the potential for dairy-based supplements to slow the rate of decline in individuals with quantifiable Age-Associated Memory Impairment (AAMI). These individuals are particularly interesting given the absence of underlying pathology (e.g., dementia) explaining their decline and the fact that they do not yet meet criteria for MCI [43].…”

Section: Discussionmentioning

confidence: 99%

The Effect of Whey and Soy Protein Isolates on Cognitive Function in Older Australians with Low Vitamin B12: A Randomised Controlled Crossover Trial

et al. 2018

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Whey protein isolate (WPI) is high in vitamin B12 and folate. These and other related markers (holotranscobalamin, methylmalonic acid and homocysteine) have been linked with cognitive health. This study explored the efficacy of WPI for improving cognitive function via delivery of vitamin B12. Moderately vitamin B12-deficient participants aged between 45 and 75 years (n = 56) were recruited into this randomised controlled crossover trial. Participants (55% female) consumed 50 g whey (WPI; active) or soy protein isolate (SPI; control) for eight weeks. Following a 16-week washout phase, they consumed the alternative supplement. Consumption of WPI significantly improved active B12 and folate status but did not result in direct improvements in cognitive function. However, there was evidence of improvement in reaction time (p = 0.02) and reasoning speed (p = 0.04) in the SPI condition for females. Additional analyses showed that changes in active B12, HcY and folate measures during WPI treatment correlated with improvements in cognitive function (all p < 0.05). Results indicate that WPI itself did not result in improved cognitive function but some evidence of benefit of SPI for females was found. However, consistent with previous research, we present further evidence of a role for active B12, HcY and folate in supporting cognitive improvement in adults with low B vitamin status.

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P3‐238: Age‐associated memory impairment increases risk of conversion to MCI and dementia

Cited by 2 publications

References 0 publications

The Effects of Vitamin D-Enriched Mushrooms and Vitamin D3 on Cognitive Performance and Mood in Healthy Elderly Adults: A Randomised, Double-Blinded, Placebo-Controlled Trial

The Effects of Vitamin D-Enriched Mushrooms and Vitamin D3 on Cognitive Performance and Mood in Healthy Elderly Adults: A Randomised, Double-Blinded, Placebo-Controlled Trial

The Effect of Whey and Soy Protein Isolates on Cognitive Function in Older Australians with Low Vitamin B12: A Randomised Controlled Crossover Trial

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