P3–201: Studies on the effect of the apolipoprotein E genotype on the lipid profile in Alzheimer's disease

Sabbagh, Marwan N.; Sandhu, Shawn; Kolody, Heather; Lahti, Tyson; Silverberg, Nina; Sparks, D. Larry

doi:10.1016/j.jalz.2006.05.1470

Cited by 2 publications

(2 citation statements)

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“…Though there were slightly raised leptin levels in AD patients with APO E ε4 allele, but they were not significant. Similar findings have been reported by Sabbagh et al ., 2006,[ 60 ] which showed that APO E ε4 allele did not reveal any significant difference in the lipid profile except for LDL-C, whereas, Neeraj et al ., 2012[ 40 ] reported significantly high levels of serum cholesterol and LDL-C cholesterol in APO E ε3/4 genotype in patients with AD as compared to controls. Studies done by Staito et al ., 2003[ 61 ] shows that APO E ε4 isoforms have higher capacity to bind to VLDL receptor leading to raised levels of serum cholesterol and LDL-C.…”

Section: Discussionmentioning

confidence: 99%

Effect of apolipoprotein E (APO E) polymorphism on leptin in Alzheimer′s disease

Agarwal¹,

Talwar²,

Kushwaha³

et al. 2015

Ann Indian Acad Neurol

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Background:Leptin, a 16 kDa peptide hormone synthesized and secreted specifically from white adipose cells protects neurons against amyloid β-induced toxicity, by increasing Apolipoprotein E (APO E)-dependent uptake of β amyloid into the cells, thereby, protect individuals from developing Alzheimer's disease (AD). The APO E ε4 allele is a known genetic risk factor for AD by accelerating onset. It is estimated that the lifetime risk of developing AD increases to 29% for carriers with one ε4 allele and 9% for those with no ε4 allele.Objectives:To determine the levels of serum leptin, cholesterol, low density lipoprotein (LDL-C), and high density lipoprotein (HDL-C) in the diagnosed cases of AD and the association of them with cognitive decline and Apolipoprotein E (APO E) genotypes in AD.Materials and Methods:Serum levels of serum leptin, cholesterol, LDL-C, and HDL-C along with APO E polymorphism were studied in 39 subjects with probable AD and 42 cognitive normal individuals.Results:AD group showed significantly lower levels of leptin (P = 0.00) as compared to control group. However, there was no significant difference in cholesterol, triglycerides, LDL-C, and HDL-C levels in AD and control groups. The frequency of ε4 allele in AD (38.5%) was found to be significantly higher than in control (10.3%). ε3 allele was more frequent than ε4 allele in AD and control group.

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Section: Discussionmentioning

confidence: 99%

Effect of apolipoprotein E (APO E) polymorphism on leptin in Alzheimer′s disease

Agarwal¹,

Talwar²,

Kushwaha³

et al. 2015

Ann Indian Acad Neurol

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“…Briefly, lipidomics involves the identification and quantification of lipids in biological systems 9) . Studies have shown that certain diseases (e.g., Alzheimer's disease, schizophrenia, bipolar disorder, multiple sclerosis, chronic kidney failure, and cystic fibrosis) and cancers (e.g., prostate, insulin growth factor receptor-2 (IGFR-2)positive metastatic breast, and colorectal cancers) are closely related to changes in lipid ratio and that some lipid molecules are associated with the development of certain diseases 1,8,10,13,17,22,24,25,28,30,34,37,39,41,43,44) . The outcomes of the studies suggest that alterations in the lipid profiles of different lipid types specific to different diseases can be used as biomarkers for that disease.…”

Section: Introductionmentioning

confidence: 99%

Investigating the Potential of Lipids for Use as Biomarkers for Glioblastoma via an Untargeted Lipidomics Approach

Söylemez

Bulut

Şahin‐Bölükbaşı

2023

J Korean Neurosurg Soc

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Objective :The types and functions of lipids involved in glioblastoma (GB) are not well known. Lipidomics is a new field that examines cellular lipids on a large scale and novel aplication of lipidomics in the biomedical sciences have emerged. This study aimed to investigate the potential of blood lipids for use as biomarkers for the diagnosis of GB via untargated lipidomic approach. Gaining a deeper understanding of lipid metabolism in patients with GB can contribute to the early diagnosis with GB patiens and also development of novel and better therapeutic options. Methods : This study was performed using blood samples collected from 14 patients (eight females and six males) and 14 controls (eight females and six males). Lipids were extracted from blood samples and quantified using phosphorus assay. Lipid profiles of between patients with GB and controls were compared via an untargeted lipidomics approach using 6530 Accurate-Mass Q-TOF LC/MS mass spectrometer. Results : According to the results obtained using the untargeted lipidomics approach, differentially regulated lipid species, including fatty acid (FA), glycerolipid (GL), glycerophospholipid (PG), saccharolipid (SL), sphingolipid (SP), and sterol lipid (ST) were identified between in patients with GB and controls. Conclusion : Differentially regulated lipids were identified in patients with GB, and these lipid species were predicted as potential biomarkers for diagnosis of GB.

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P3–201: Studies on the effect of the apolipoprotein E genotype on the lipid profile in Alzheimer's disease

Cited by 2 publications

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Effect of apolipoprotein E (APO E) polymorphism on leptin in Alzheimer′s disease

Effect of apolipoprotein E (APO E) polymorphism on leptin in Alzheimer′s disease

Investigating the Potential of Lipids for Use as Biomarkers for Glioblastoma via an Untargeted Lipidomics Approach

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