Abstract:Background: Many studies on Alzheimer's disease (AD) focus solely on how neuronal proteins change in the brain, so little is known about what is happening to these same proteins in peripheral tissues. For example, it is known that tau is present within the human submandibular gland and that levels of some tau variants are inversely relate to Braak neurofibrillary tangle (NFT) stage. However, it is unclear if other neuronal proteins may also be detected in the submandibular gland and whether their levels are al… Show more
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