P3‐111: Cognitive assessment: Discrimination of impairment and detection of decline in Alzheimer's disease and mild cognitive impairment

Chandler, Julie; Marsico, Mark; Harper-Mozley, Lyn; Vogt, Renee; Peng, Yahong; Lesk, Valerie E.; Jager, Celeste de

doi:10.1016/j.jalz.2008.05.1676

Cited by 9 publications

(7 citation statements)

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“…This is further supported by findings from our linear regression model, where the PAL task accurately predicted MoCA total score after adjusting for age, gender, and total years of education. These findings are in line with previous studies that demonstrate the utility of the PAL task for assessing global cognition (Chandler et al, 2008;Egerhazi et al, 2007;Fowler et al, 2002;Smith et al, 2013). In our study, all MoCA subdomain scores were associated with the PAL task performance.…”

Section: Discussionsupporting

confidence: 93%

Associations of visual paired associative learning task with global cognition and its potential usefulness as a screening tool for Alzheimer’s Dementia

Hicks

Ahsan

Bhandari

et al. 2020

Int. Psychogeriatr.

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Objective: Appropriate screening is integral to the early diagnosis and management of Alzheimer’s Dementia (AD). The Paired Associates Learning (PAL) task is a digital cognitive task that is free of cultural, language, and educational biases. This study examined the association between the PAL task performance and global cognition and the usefulness of the PAL task as a screening tool for AD. Design: Cross-sectional. Setting: Academic hospital. Methods: Twenty-five participants with AD and 22 healthy comparators (HC) were included. The Cambridge Neuropsychological Test Automated Battery PAL task and the Montreal Cognitive Assessment (MoCA) were used to assess cognition. We assessed the relationship between the PAL task and MoCA performance using Pearson correlation and linear regression. We also examined the PAL task’s ability to distinguish between AD and HC participants using Receiver Operating Characteristic curve (ROC) analysis. Measurements: MoCA Total Score had a strong positive correlation with PAL Stages Completed score (r = 0.8, p < 0.001), and a strong negative correlation with PAL Total Errors (adjusted) score (r = −0.9, p < 0.001). Further, PAL Total Errors (adjusted) score predicted the MoCA Total Score (F (4, 46) = 37.2, p < 0.001). On ROC analysis, PAL Total Errors (adjusted) score cut-off of 54 errors had 92% sensitivity and 86% specificity to detect AD. Conclusions: Performance on the PAL task is highly associated with global cognition. Further, the PAL task can differentiate patients with AD from HCs with high sensitivity and specificity. Thus, the PAL task may hold potential usage as an easy-to-administer screening tool for AD.

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Section: Discussionsupporting

confidence: 93%

Associations of visual paired associative learning task with global cognition and its potential usefulness as a screening tool for Alzheimer’s Dementia

Hicks

Ahsan

Bhandari

et al. 2020

Int. Psychogeriatr.

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“…Participants completed two online cognitive assessments, PAL and SWM, from the CANTAB battery, validated in MCI and AD. 18 , 19 , 20 , 21 , 22 …”

Section: Methodsmentioning

confidence: 99%

“…The PALTEA6 score is the total errors at the six‐pattern stage, adjusted for incomplete or failed trials. PAL scores distinguish between older adults with MCI and healthy controls with a sensitivity/specificity of 0.83/0.82, 18 and longitudinal decline predicts progression from MCI to AD. 19 …”

Section: Methodsmentioning

confidence: 99%

Estimating presymptomatic episodic memory impairment using simple hand movement tests: A cross‐sectional study of a large sample of older adults

Wang

George

Bindoff

et al. 2023

Alzheimer's & Dementia

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INTRODUCTIONFinding low‐cost methods to detect early‐stage Alzheimer's disease (AD) is a research priority for neuroprotective drug development. Presymptomatic Alzheimer's is associated with gait impairment but hand motor tests, which are more accessible, have hardly been investigated. This study evaluated how home‐based Tasmanian (TAS) Test keyboard tapping tests predict episodic memory performance.METHODS1169 community participants (65.8 ± 7.4 years old; 73% female) without cognitive symptoms completed online single‐key and alternate‐key tapping tests and episodic memory, working memory, and executive function cognitive tests.RESULTSAll single‐key (R2adj = 8.8%, ΔAIC = 5.2) and alternate‐key (R2adj = 9.1%, ΔAIC = 8.8) motor features predicted episodic memory performance relative to demographic and mood confounders only (R2adj = 8.1%). No tapping features improved estimation of working memory.DISCUSSIONBrief self‐administered online hand movement tests predict asymptomatic episodic memory impairment. This provides a potential low‐cost home‐based method for stratification of enriched cohorts.Highlights We devised two brief online keyboard tapping tests to assess hand motor function. 1169 cognitively asymptomatic adults completed motor‐ and cognitive tests online. Impaired hand motor function predicted reduced episodic memory performance. This brief self‐administered test may aid stratification of community cohorts.

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“…To date, > 14,000 people have been recruited to the ISLAND Project; 8,500 research participants (mean age 63 years) have provided detailed demographic and health data, 3,000 have completed the online validated Cambridge Neuropsychological Test Automated Battery (CANTAB) cognitive tests [ 47 ], 1,800 have completed online motor-cognitive tests (TAS Test) [ 38 ] and more than 1,500 have provided blood samples. Paired Associates Learning (PAL) scores distinguish between older adults with MCI and those who are cognitively healthy with a sensitivity/specificity of 0.83/0.82 [ 48 ]. The online ISLAND Project surveys are repeated annually with cognitive performance and blood-based biomarkers collected every second year.…”

Section: Methodsmentioning

confidence: 99%

Development of a smartphone screening test for preclinical Alzheimer’s disease and validation across the dementia continuum

Alty,

Goldberg,

Roccati

et al. 2024

BMC Neurol

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Background Dementia prevalence is predicted to triple to 152 million globally by 2050. Alzheimer’s disease (AD) constitutes 70% of cases. There is an urgent need to identify individuals with preclinical AD, a 10–20-year period of progressive brain pathology without noticeable cognitive symptoms, for targeted risk reduction. Current tests of AD pathology are either too invasive, specialised or expensive for population-level assessments. Cognitive tests are normal in preclinical AD. Emerging evidence demonstrates that movement analysis is sensitive to AD across the disease continuum, including preclinical AD. Our new smartphone test, TapTalk, combines analysis of hand and speech-like movements to detect AD risk. This study aims to [1] determine which combinations of hand-speech movement data most accurately predict preclinical AD [2], determine usability, reliability, and validity of TapTalk in cognitively asymptomatic older adults and [3], prospectively validate TapTalk in older adults who have cognitive symptoms against cognitive tests and clinical diagnoses of Mild Cognitive Impairment and AD dementia. Methods Aim 1 will be addressed in a cross-sectional study of at least 500 cognitively asymptomatic older adults who will complete computerised tests comprising measures of hand motor control (finger tapping) and oro-motor control (syllabic diadochokinesis). So far, 1382 adults, mean (SD) age 66.20 (7.65) years, range 50–92 (72.07% female) have been recruited. Motor measures will be compared to a blood-based AD biomarker, phosphorylated tau 181 to develop an algorithm that classifies preclinical AD risk. Aim 2 comprises three sub-studies in cognitively asymptomatic adults: (i) a cross-sectional study of 30–40 adults to determine the validity of data collection from different types of smartphones, (ii) a prospective cohort study of 50–100 adults ≥ 50 years old to determine usability and test-retest reliability, and (iii) a prospective cohort study of ~1,000 adults ≥ 50 years old to validate against cognitive measures. Aim 3 will be addressed in a cross-sectional study of ~200 participants with cognitive symptoms to validate TapTalk against Montreal Cognitive Assessment and interdisciplinary consensus diagnosis. Discussion This study will establish the precision of TapTalk to identify preclinical AD and estimate risk of cognitive decline. If accurate, this innovative smartphone app will enable low-cost, accessible screening of individuals for AD risk. This will have wide applications in public health initiatives and clinical trials. Trial registration ClinicalTrials.gov identifier: NCT06114914, 29 October 2023. Retrospectively registered.

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P3‐111: Cognitive assessment: Discrimination of impairment and detection of decline in Alzheimer's disease and mild cognitive impairment

Cited by 9 publications

References 0 publications

Associations of visual paired associative learning task with global cognition and its potential usefulness as a screening tool for Alzheimer’s Dementia

Associations of visual paired associative learning task with global cognition and its potential usefulness as a screening tool for Alzheimer’s Dementia

Estimating presymptomatic episodic memory impairment using simple hand movement tests: A cross‐sectional study of a large sample of older adults

Development of a smartphone screening test for preclinical Alzheimer’s disease and validation across the dementia continuum

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