P3.11-02 Lung Cancer Screening in a High Incidence Population: Results of Low-Dose CT Screenings in a Northern Kentucky Community Healthcare System

Abstract

examination. Thus, we selected the other 22 cases without occult LN metastasis by matching gender, age, smoking history and tumor histology. Hypermethylation on 32 genes, such as TNFRSF1B, DMRTA2, VAV3-AS1, HIST3H2A, PALD1, NKX2-3, MAP3K12, MAPK10, were identified between the two groups. Hypomethylation on 20 genes, such as RAB42, KCNN3, UBE2L6, RARG, CRY1, MTUS2, TMEM179, MEGF11, were also detected. 25% (13 out of 52 genes) of these markers could be found in the matched tissue samples. The AUC of tenfold cross validation of the preliminary prediction model is 0.86. Conclusion: We found some specific plasma methylation markers for occult LN metastasis of NSCLC. Further efforts should be made in establishing a non-invasive blood diagnostic tool.