P3.07-02 Expectations, Standards and Performance Framework to Support the Lung Cancer Support Nurse in Lung Foundation Australia

Abstract

Background: The majority of NSCLC patients treated with immunecheckpoint inhibitors (ICI) develop acquired resistance. Conventional cytotoxic chemotherapy remains the treatment of choice for those patients. There are case reports on re-administration of ICIs for advanced NSCLC; however, these case series are difficult to draw definitive conclusions. We therefore retrospectively reviewed the efficacy of retreatment with ICI in our hospital. Method: Patients with pathologically confirmed advanced NSCLC who were treated with ICI in Kindai University hospital were retrospectively reviewed from December 2015 to July 2017. Among 212 NSCLC patients treated with ICIs, 10 patients (4.7 %) were retreated with ICI. Result: Number of patients treated with Nivolumab, Pembrolizumab and Atezolizumab were four, five and one, respectively. The best response of initial treatment with ICIs among 10 patients were five partial response (PR), two stable disease (SD) and three progressive disease (PD). Whereas, three patients (30%) showed SD and the others (70%) had PD to ICI retreatment. No severe adverse events attributable to the ICIs were noted. Conclusion: In the limited number of retrospective study, we could not find good responders for retreatment with ICIs. Best overall response during the previous treatment period is not related to the efficacy of retreatment with ICIs. At present, former responder to ICI therapy may not be the proper candidate for ICI re-challenge treatment strategy. Further biomarker analysis and treatment strategy is warranted for the patients and physicians to retreat with ICIs.

Effects of ADOPT-Based Breathing Training Combined with Continuous Nursing on Quality of Life, Mental Health, and Self-Efficacy in Lung Cancer Patients Undergoing Chemotherapy: Based on a Retrospective Cohort Study

“…For example, the complete breathing method in yoga breathing method can fully open the chest cavity through the combination of chest breathing method and abdominal breathing method, so that the main respiratory muscles of the human body, namely, diaphragm, intercostal muscle, and abdominal muscle, are involved in breathing exercise, so that the alveoli of the upper, middle, and lower lungs are involved in gas exchange, which can reduce dead space-like ventilation, improving ventilation and perfusion of poor pulmonary ventilation [ 18 ]. Clean breathing is a rapid abdominal breathing, through rapid abdominal contraction, pushing the diaphragm to squeeze the lungs so that respiratory secretions are excreted from the airway along with the air, which can reduce the retention of respiratory secretions; alternative nostril breathing alternately through the left and right nostrils for chest breathing can selectively activate the autonomic nervous system, resulting in a significant sedative effect [ 19 ]. However, patients' compliance with yoga breathing training is an important prerequisite to affect its effect.…”

TSANZ Abstracts

“…VCAM-1 remained predictive of mortality following adjustment for DLCO%, pulmonary hypertension, age, gender and ILD (HR 2.76,p < 0.01). The association between VCAM-1 and mortality remained true for participants with ILD (HR 4.04, 2.37-6.90), early SSc (HR 6.57;diffuse (HR 3.72;) and limited disease (HR 3.68; TO 112 | Determinants of sedentary behaviour and time spent in moderate-vigorous physical activity in ILD Dowman L 1,2,3,4 , May A 1 , Hill C 2,4 , Bondarenko J 1,5 ,McDonald C 2,3,6 , Glaspole I 7,8 , Goh N 3,6,7 , Holland A Methods: Multiple hPCLS (500 μm thick) were prepared from agarose-inflated non-IPF lung resections or donor lungs not used for transplant (n = 5). PCLS were treated for 120 h with fibrotic cocktail (FC = TGFβ, LPA, PDGF-AB and TNFα) +/relaxin (100 nM) or pirfenidone (500 μM).…”

“…TO 014 | Patient experiences with maintenance oral corticosteroid use in severe asthma Harrington J 1,2 , Harvey E 1,2 , Stevens S 1 , Thomas D 1 , McDonald V 1,2,3 , Gibson P 1,2,3 1 John Hunter Hospital, Newcastle, Australia, 2 College of Health Medicine and Wellbeing, University of Newcastle, Newcastle, Australia, 3 Australian Severe Asthma Network, Newcastle, Australia Key Words: asthma, corticosteroids, mepolizumab, comorbidity. Introduction/Aim: Maintenance oral corticosteroids (mOCS) carry serious health risks.…”

“…Grant Support: Nil. , Jee A2,3,4 , Hansen D 5 , Youssef P 1,2 , Stevens W 5 , Proudman S 6,7 , Nikpour M 5,8 , Sahhar J 9,10 , Corte T2,3,4 1 Institute of Rheumatology and Orthopaedics, Royal Prince Alfred Hospital, Sydney, Australia, 2 School of Medicine, University of Sydney Faculty of Medicine and Health, Sydney, Australia, 3 NHMRC Centre of Research Excellence in Pulmonary Fibrosis, Australia, 4 Department of Respiratory, Royal Prince Alfred Hospital, Sydney, Australia, 5 Department of Rheumatology, St Vincent's Hospital, Melbourne, Australia, 6 Rheumatology Unit, Royal Adelaide Hospital, Adelaide, Australia, 7 Discipline of Medicine, University of Adelaide, Adelaide, Australia, 8 Department of Medicine, The University of Melbourne, St. Vincent's Hospital, Melbourne, Australia, 9 Department of Inflammatory Diseases, Monash Health, Melbourne, Australia, 10 Department of Medicine, Central Clinical School, Monash University, Melbourne, Australia Introduction/Aim: Systemic sclerosis (SSc) is a systemic autoimmune disease with significant morbidity and mortality. Risk factors for mortality in SSc include increased age, male gender and pulmonary fibrosis as determined by CT scan or pulmonary function.…”

“…1,2,4 1 Respiratory Research@Alfred, Central Clinical School, Monash University, Melbourne, Australia,2 Institute for Breathing and Sleep, Melbourne, Australia,3 Department of Respiratory and Sleep Medicine, Melbourne, Australia, 4 Department of Physiotherapy, Austin Health, Melbourne, Australia, 5 Department of Physiotherapy, Alfred Health, Melbourne, Australia, 6 Melbourne Medical School, University of Melbourne, Melbourne, Australia, 7 Department of Respiratory Medicine, Alfred Hospital, Melbourne, Australia, 8 Clinical School, Monash University, Melbourne, AustraliaIntroduction/Aim: Physical activity is reduced in people with interstitial lung disease (ILD); however, there is less information on sedentary behaviour, an important health risk factor independent of physical activity, and factors that influence time spent in moderate-vigorous physical activity (MVPA). This study aimed to investigate the relationship between sedentary behaviour, time spent in MVPA, exercise capacity and disease severity in people with ILD.…”