P2X7 receptors in the nervous system

Sperlágh, Beáta; Vizi, E.S.; Wirkner, Kerstin; Illéš, Peter

doi:10.1016/j.pneurobio.2006.03.007

Cited by 346 publications

(306 citation statements)

References 212 publications

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“…The P2X 7 R was first discovered by Buisman in 1988 and Gordon named it the P2z receptor [15] meaning ''cell death receptor'' [3] or "suicide receptor" [5] because its prolonged activation leads to cellular death. In 1996, the P2X 7 R was first cloned from a rat brain cDNA library and classified as a member of the P2X receptor family [7] .…”

Section: Compared With Other P2x Family Receptorsmentioning

confidence: 99%

“…On the other hand, pathological events such as mechanical or metabolic stress, inflammation, cellular injury, or changes in the ionic environment are all known to powerfully stimulate ATP release. This results in an ATP-rich extracellular environment leading to widespread activation of receptors on astrocytes and microglia and boosting diverse pathological cascades, such as glutamatergic excitotoxicity, and oxidative damage, as well as IL-1β and other cytokine-mediated signaling [3] . P2 receptors are classified into two subfamilies, P2X and P2Y.…”

Section: Introductionmentioning

confidence: 99%

“…Seven distinct ionotropic P2X (P2X [1][2][3][4][5][6][7] and eight distinct metabotropic P2Y receptor subunits (P2Y 1,2,4,6,[11][12][13][14], classified by electrophysiological properties and their amino-acid sequence homology, have been cloned from mammals [4] .…”

Section: Introductionmentioning

confidence: 99%

“…Of the P2X family, the P2X 7 receptor (P2X 7 R) has specific structural and pharmacological features and may play a prominent role in the progression of various neurological disorders, such as cerebral ischemic injury (stroke), [3,7,8] . In the past few years, the potential role of this receptor in neuronal functions during cerebral ischemic stroke has received considerable attention.…”

Section: Introductionmentioning

confidence: 99%

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P2X7 receptors in cerebral ischemia

Bai

2013

Neurosci. Bull.

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Cerebral ischemia is one of the most common diseases resulting in death and disability in aged people. It leads immediately to rapid energy failure, ATP depletion, and ionic imbalance, which increase extracellular ATP levels and accordingly activate P2X 7 receptors. These receptors are ATP-gated cation channels and widely distributed in nerve cells, especially in the immunocompetent cells of the brain. Currently, interest in the roles of P2X 7 receptors in ischemic brain injury is growing. In this review, we discuss recent research progress on the actions of P2X 7 receptors, their possible mechanisms in cerebral ischemia, and the potential therapeutic value of P2X 7 receptor antagonists which may provide a new target both for clinical and for research purposes.

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Section: Compared With Other P2x Family Receptorsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

P2X7 receptors in cerebral ischemia

Bai

2013

Neurosci. Bull.

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“…The neurons cannot be replaced once lost and the visual signal they convey to the brain is consequently gone. However, the recognition that P2X 7 receptors are distributed throughout the nervous system and may contribute to the complex signaling between neurons and glial cells suggests these P2X 7 receptors normally function in a benign fashion in adult retinal ganglion cells [1,2].…”

mentioning

confidence: 99%

The P2X7 receptor in retinal ganglion cells: A neuronal model of pressure-induced damage and protection by a shifting purinergic balance

Mitchell

et al. 2008

Purinergic Signalling

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Retinal ganglion cells process the visual signal and transmit it along their axons in the optic nerve to the brain. Molecular, immunohistochemical, and functional analyses indicate that the majority of retinal ganglion cells express the ionotropic P2X 7 receptor. Stimulation of the receptor can lead to a rise in intracellular calcium and cell death, although death does not involve the opening of a large diameter pore. Adenosine acting at A 3 receptors can attenuate the rise in calcium and death accompanying P2X 7 receptor activation, suggesting that dephosphorylation of ATP into adenosine is neuroprotective and that the balance of extracellular purines can influence neuronal survival. Increased intraocular pressure can lead to release of excessive extracellular ATP in the retina and damage ganglion cells by acting on P2X 7 receptors, implicating a role for the receptor in the loss of ganglion cell activity in glaucoma. In summary, the activation of P2X 7 receptors has both physiologic and pathophysiologic implications for ganglion cell function. These characteristics may also provide an insight into the contributions the P2X 7 receptor makes to neurons elsewhere.

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Association between depression and the Gln460Arg polymorphism of P2RX7 Gene: A dimensional approach

Hejjas

Székely

Dömötör

et al. 2008

American J of Med Genetics Pt B

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The P2RX7 gene (coding for P2X7 purinergic receptor) has been suggested as a novel candidate gene for major depressive disorder (MDD) and bipolar disorder (BPD). The proposed risk allele (G-allele) of the rs2230912 polymorphism results in an amino acid change at the 460th position, marking this genetic variation a possibly functional one. Here we present a case-control analysis of 171 patients diagnosed with MDD or BPD and 178 controls, as well as a dimensional approach using the Hospital Anxiety and Depression Scale (HADS) for studying the Gln460Arg polymorphism of the P2RX7 gene as a genetic risk factor in depression. While case-control analysis did not show significant difference between the groups, a significant association was found between the P2RX7 polymorphism and the HADS scales in the clinical group (MANOVA P = 0.001). Both anxiety and depression scores increased as the number of G-allele increased in the genotype groups (ANOVA for HADS-anxiety: P = 0.01, HADS-depression: P < 0.001). A significant interaction of clinical status and the P2RX7 polymorphism was also found for the depression scale (MANOVA P = 0.025, subsequent ANOVA for anxiety: P = 0.252; depression: P = 0.002). Whereas patients with G-allele-present genotypes showed more elevated depression scores, level of depression in the control group was not affected by the P2RX7 genotype. In conclusion, case-control analysis did not reveal significant results, but using a symptom severity scale we could support the association between depressive disorder and the G-allele of the Gln460Arg polymorphism in the P2RX7 gene.

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P2X7 receptors in the nervous system

Cited by 346 publications

References 212 publications

P2X7 receptors in cerebral ischemia

P2X7 receptors in cerebral ischemia

The P2X7 receptor in retinal ganglion cells: A neuronal model of pressure-induced damage and protection by a shifting purinergic balance

Association between depression and the Gln460Arg polymorphism of P2RX7 Gene: A dimensional approach

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