P2X7 receptor in spinal tuberculosis: Gene polymorphisms and protein levels in Chinese Han population

Zhou, Ying; Tan, Chee Eng; Zhang, Mo; Gao, Qile; He, Dan; Li, Jiong; Huang, Rongfu; Li, Yanbing; Guo, Chaofeng; Guo, Qiang; Wang, Long-jie; Yang, Guanteng; Zhang, Hongqi

doi:10.1016/j.meegid.2017.11.020

Cited by 7 publications

(8 citation statements)

References 41 publications

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“…Both the pulmonary imaging results and clinical manifestations are similar to tuberculosis, which showed nodes, cavities or infiltration in lungs, especially when histoplasma capsulatum impairs the lung tissues and patients show nonspecific pulmonary symptoms . Physicians are supposed to distinguish the two diseases considering that China has the second highest burden of TB worldwide, accounting for 11% of global tuberculosis incidence . In this study, 13 cases were misdiagnosed with tuberculosis, septicemia, malignant lymphoma and connective tissue diseases, respectively, and two cases were diagnosed with other mycoses without considering histoplasmosis.…”

Section: Discussionmentioning

confidence: 75%

“…18,19 Physicians are supposed to distinguish the two diseases considering that China has the second highest burden of TB worldwide, accounting for 11% of global tuberculosis incidence. [20][21][22] In this study, 13 cases were misdiagnosed with tuberculosis, septicemia, malignant lymphoma and connective tissue diseases, respectively, and two cases were diagnosed with other mycoses without considering histoplasmosis.…”

Section: Discussionmentioning

confidence: 84%

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Clinical features and endemic trend of histoplasmosis in China: A retrospective analysis and literature review

Jiang

et al. 2020

Clinical Respiratory J

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Introduction Histoplasmosis is a rare mycosis with nonspecific clinical manifestation and a high misdiagnosis rate, which is an epidemic disease that occurred in several endemic areas. Cases of histoplasmosis were sporadic in China. Objective We detected the clinical characteristics and endemic trend of histoplasmosis to understand it more profoundly. Method The clinical data of 34 cases of histoplasmosis hospitalized in Xiangya Hospital of Central South University from 2003 to 2016 were analyzed retrospectively. The relevant literature were reviewed roundly which were about histoplasmosis from 2001 to 2019 reported in the Chinese mainland. Results Thirty‐four patients were included in the study, male predominance. About 44.1% were combined with underlying disease and HIV infection was observed in eight patients. Common clinical manifestations were fever (94.1%), followed by lymphadenopathy (70.6%) and anemia (67.6%). Organ involvement included lungs (52.9%), oral cavity (5.9%) and intestine (5.9%). Patients were diagnosed by bone marrow smears (44.1%), lymph node biopsy (41.1%), lung tissue biopsy (8.8%) and intestinal tissue biopsy (5.9%). About 70.6% received amphotericin B, while 38.2% received itraconazole therapy and 79.4% were improved. About 611 cases of histoplasmosis in the Chinese mainland were obtained in the study from the related literature, with 217 (37.0%) cases occurred in Yunnan province, 69 (11.9%) cases in Hunan province and 67 (11.6%) cases in Hubei province. All of them were high incidence area of histoplasmosis. Conclusion Histoplasmosis is a rare mycosis with high diagnosis rate and has a prominent geographical distribution in China, which should be considered highly in clinical work.

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Section: Discussionmentioning

confidence: 75%

Section: Discussionmentioning

confidence: 84%

Clinical features and endemic trend of histoplasmosis in China: A retrospective analysis and literature review

Jiang

et al. 2020

Clinical Respiratory J

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“…Through a comprehensive literature search and selection based on the inclusion criteria, 59 relevant case-control studies from 24 selected articles [12,13,14,15,16,17,18,19,20,21,22,23,24,25,26,27,28,29,30,31,32,33,34,35] were included in the pooled analysis. There were 30 studies with 5247 cases and 7614 controls on rs3751143 (1513A > C), 19 studies with 3235 cases and 4685 controls on rs2393799 (−762 C > T), 3 studies with 2185 cases and 2107 controls on rs1718119 (Thr348Ala), 3 studies with 1994 cases and 2037 controls on rs208294 (His155Tyr), 2 studies with 2000 cases and 2006 controls on rs7958311, 2 studies with 1853 cases and 1797 controls on rs2230911 included into meta-analysis.…”

Section: Resultsmentioning

confidence: 99%

“…Several single nucleotide polymorphisms (SNPs) have been revealed that affect the function of this receptor which cause P2X7R loss-of-function (LOF) or gain-of-function (GOF) [8]. Many studies have inspected the association between P2X7 polymorphisms and risk of tuberculosis in various populations, but the findings were inconsistent [12,13,14,15,16,17,18,19,20,21,22,23,24,25,26,27,28,29,30,31,32,33,34,35]. So we conducted an updated meta-analysis of all available eligible case-control studies published to date, focusing on the association between P2X7 polymorphisms and tuberculosis risk.…”

Section: Introductionmentioning

confidence: 99%

Association between P2X7 Polymorphisms and Susceptibility to Tuberculosis: An Updated Meta-Analysis of Case-Control Studies

et al. 2019

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Background and Objectives: Several studies inspected the impact of P2X7 polymorphisms on individual susceptibility to tuberculosis (TB), but the findings are still controversial and inconclusive. To achieve a more precise estimation, we conducted a meta-analysis of all eligible studies on the association between P2X7 polymorphisms and TB risk. Materials and Methods: Relevant studies were identified by searching the PubMed, Web of Science, Scopus and Google scholar databases up to November 2018. Twenty-four full-text articles were included in our meta-analysis. The strength of association between P2X7 polymorphisms and TB risk was evaluated by odds ratios (ORs) and 95% confidence intervals (95% CIs) under five genetic models. Results: The findings of this meta-analysis revealed that the rs3751143 variant significantly increased the risk of TB in heterozygous codominant (OR = 1.44, 95%CI = 1.17−1.78, p = 0.0006, AC vs. AA), homozygous codominant (OR = 1.87, 95% CI = 1.40−2.49, p = 0.0004, CC vs. AA), dominant (OR = 1.50, 95% CI = 1.22−1.85, p = 0.0002, AC + CC vs. AA), recessive (OR = 1.61, 95% CI = 1.25−2.07, p = 0.001, CC vs. AC + AA), and allele (OR = 1.41, 95% CI = 1.19−1.67, p < 0.0001, C vs. A) genetic models. Stratified analysis showed that rs3751143 increased the risk of pulmonary tuberculosis (PTB) and extrapulmonary tuberculosis (EPTB) in all genetic models. Furthermore, the rs3751143 increased risk of TB in the Asian population. The findings did not support an association between the rs2393799, rs1718119, rs208294, rs7958311, and rs2230911 polymorphisms of P2X7 and TB risk. Conclusions: The findings of this meta-analysis suggest that P2X7 rs3751143 polymorphism may play a role in susceptibility to TB in the Asian population. More well-designed studies are required to elucidate the exact role of P2X7 polymorphisms on TB development.

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“…The active TB prevalence rate in China was 5% in 2010, and every 3% to 5% of active TB cases involves dissolved bone lesions, most of which occur in the spine. [ 10 ] Spinal lesions may lead to pain, nerve compression symptoms and paraplegia. Some studies have shown that spinal TB patients have different pathologic and predisposing factors.…”

Section: Discussionmentioning

confidence: 99%

Migration inhibitory factor in spinal tuberculosis: -173G/C polymorphisms, and transcript and protein levels in a northern province of China

Wang

Sheng

et al. 2020

Medicine

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The aim of this study was to elucidate the possible association between migration inhibitory factor (MIF)-173G/C gene polymorphisms and transcript and plasma levels of MIF in spinal tuberculosis (TB) patients. Clinical data were collected from 254 spinal TB patients and 262 healthy controls participating in the study. The genotype of the MIF-173G/C gene was amplified by polymerase chain reaction and genotyped by DNA sequencing technology. The level of mRNA expression was determined by real-time polymerase chain reaction and MIF plasma levels were measured by a solid-phase enzyme-linked immunosorbent assay. The frequency of the C allele and GC+CC genotype in MIF-173G/C was over-represented in spinal TB patients. The mean MIF mRNA level in spinal TB patients and patients with the GG and GC+CC genotype were significantly lower than controls; however, our study also indicated that the MIF concentration in spinal TB patients and patients with the GG and GC+CC genotypes were significantly higher than controls. Spinal TB patients with the GG genotype had higher MIF plasma levels than patients with the GC+CC genotype. The C-reactive protein level and erythrocyte sedimentation rate was correlated with the MIF plasma level. In summary, the association between the MIF-173G/C genetic polymorphism, reduced transcript and increased plasma levels of MIF in spinal TB patients, and MIF may play an important role in the occurrence, development, and damage of spinal TB in the northern Province population of China.

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P2X7 receptor in spinal tuberculosis: Gene polymorphisms and protein levels in Chinese Han population

Cited by 7 publications

References 41 publications

Clinical features and endemic trend of histoplasmosis in China: A retrospective analysis and literature review

Clinical features and endemic trend of histoplasmosis in China: A retrospective analysis and literature review

Association between P2X7 Polymorphisms and Susceptibility to Tuberculosis: An Updated Meta-Analysis of Case-Control Studies

Migration inhibitory factor in spinal tuberculosis: -173G/C polymorphisms, and transcript and protein levels in a northern province of China

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