P2X7 receptor activation induces CD62L shedding from human CD4+ and CD8+ T cells

Sluyter, Ronald; Wiley, James S.

doi:10.14800/ics.92

Cited by 5 publications

(3 citation statements)

References 25 publications

(36 reference statements)

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“…In murine T cells, NAD was also able to induce P2X7-induced CD62L shedding [61,62]. ATP-induced CD62L shedding was impaired in lymphocytes, as well as monocytes, from subjects coding the P2X7 E496A loss-offunction polymorphism [60,63] and from Pfizer P2X7 knockout mice [64]. In contrast, BzATPinduced CD62L shedding was found to be more rapid in T cells from GlaxoSmithKline P2X7 knockout mice [65]; presumably due to the presence of the highly functional escape variant P2X7k in T cells from these mice [66,67].…”

Section: Cd62l (L-selectin)mentioning

confidence: 95%

“…Following the studies above, it was shown that P2X7 activation can induce CD62L shedding from human B cells and T cells [29], and subsets of these cells from humans or mice including CD27 -and CD27 + B cells [29], and CD4 + and CD8 + T cells [29, [58][59][60]. In murine T cells, NAD was also able to induce P2X7-induced CD62L shedding [61,62].…”

Section: Cd62l (L-selectin)mentioning

confidence: 99%

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Roles of extracellular nucleotides and P2 receptors in ectodomain shedding

Pupovac

Sluyter

2016

Cell. Mol. Life Sci.

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Ectodomain shedding of integral membrane receptors results in the release of soluble molecules and modification of the transmembrane portions to mediate or modulate extracellular and intracellular signalling. Ectodomain shedding is stimulated by a variety of mechanisms, including the activation of P2 receptors by extracellular nucleotides. This review describes in detail the roles of extracellular nucleotides and P2 receptors in the shedding of various cell surface molecules, including amyloid precursor protein, CD23, CD62L, and members of the epidermal growth factor, immunoglobulin and tumour necrosis factor families. This review discusses the mechanisms involved in P2 receptor-mediated shedding, demonstrating central roles for the P2 receptors, P2X7 and P2Y2, and the sheddases, ADAM10 and ADAM17, in this process in a number of cell types.

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Section: Cd62l (L-selectin)mentioning

confidence: 95%

Section: Cd62l (L-selectin)mentioning

confidence: 99%

Roles of extracellular nucleotides and P2 receptors in ectodomain shedding

Pupovac

Sluyter

2016

Cell. Mol. Life Sci.

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“…+ T cells [72,73] . This cell adhesion molecule can regulate the migration of certain T cell subsets to sites of skin inflammation [74] .…”

Section: T Cellsmentioning

confidence: 99%

P2X7 receptor in skin biology and diseases

Geraghty¹,

Watson²,

Adhikary³

et al. 2016

WJD

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The P2X7 receptor is a trimeric ligand-gated cation channel present on immune and other cells. Activation of this receptor by its natural ligand extracellular adenosine triphosphate results in a variety of downstream responses, including the release of pro-inflammatory mediators and cell death. In normal skin, P2X7 is present on keratinocytes, Langerhans cells and fibroblasts, while the presence of this receptor on other cutaneous cells is mainly inferred from studies of equivalent cell types present in other tissues. Mast cells in normal skin however express negligible amounts of P2X7, which can be upregulated in cutaneous disease. This review discusses the potential significance of P2X7 in skin biology, and the role of this receptor in inflammatory skin disorders such as irritant and chronic dermatitis, psoriasis, graft-versus-host disease, as well is in wound healing, transplantation and skin cancer. AbstractThe P2X7 receptor is a trimeric ligand-gated cation channel present on immune and other cells. Activation of this receptor by its natural ligand extracellular adenosine triphosphate results in a variety of downstream responses, including the release of pro-inflammatory mediators and cell death. In normal skin, P2X7 is present on keratinocytes, Langerhans cells and fibroblasts, while the presence of this receptor on other cutaneous cells is mainly inferred from studies of equivalent cell types present in other tissues. Mast cells in normal skin however express negligible amounts of P2X7, which can be upregulated in cutaneous disease. This review discusses the potential significance of P2X7 in skin biology, and the role of this receptor in inflammatory skin disorders such as irritant and chronic dermatitis, psoriasis, graft-versus-host disease, as well is in wound healing, transplantation and skin cancer. Core tip: The P2X7 receptor is present on immune, stromal and epithelial cells. Activation of this receptor by its natural ligand, extracellular adenosine triphosphate, causes a variety of downstream effects including release of inflammatory mediators and growth factors, as well as cell death. P2X7 has various functions on skin cells, and studies of mouse models of disease and of human cells and tissues highlight emerging roles for this receptor in common skin disorders.

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Novel therapeutic targets in uveitis

Tempest-Roe¹

2017

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P2X7 receptor activation induces CD62L shedding from human CD4+ and CD8+ T cells

Cited by 5 publications

References 25 publications

Roles of extracellular nucleotides and P2 receptors in ectodomain shedding

Roles of extracellular nucleotides and P2 receptors in ectodomain shedding

P2X7 receptor in skin biology and diseases

Novel therapeutic targets in uveitis

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