P2x Receptors as a Novel Prominent Pharmacological Target for Various CNS Disorders [
O. Iegorova,
O. Maximyuk
Abstract:Purinergic P2X receptors, particularly P2X7 and P2X4, are pivotal in brain functioning and pathology, affecting various central nervous system diseases. This review delves into P2X receptors’ roles in various pathologies, including ischemia, epilepsy, COVID-19, some neurodegenerative and psychiatric disorders. P2X7’s involvement in neuroinflammatory processes through the activation of the NLRP3 inflammasome highlights its significant role in corresponding pathologies and their treatment, as seen in studies usi… Show more
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