P293 PFT change during adjuvant hypofractionated radiation with simultaneous integrated boost for EBC

Accelerated hypofractionated adjuvant whole breast radiation with simultaneous integrated boost using volumetric modulated arc therapy for early breast cancer: A phase I/II dosimetric and clinical feasibility study from a tertiary cancer care centre of India

“…We hypothesized that early alveolar damage from initial few fractions of radiation may have been well repaired in the later phase of radiation. None of the treated patients have developed any clinical symptom or sign of pneumonitis till now [28]. The theoretical risk of second malignancy from large volume of low dose radiation though a concern, has never been able to suppress clinical use of IMRT or arc therapy considering better tumor coverage and possible scope of dose escalation [29][30][31].…”