P2637ACE inhibitors and ARBs decrease more powerful the PTX-3 plasma levels of hypertensive patients with endothelial dysfunction compared with other anti-hypertensive drugs, in a chronic treatment

Buda, Valentina; Andor, Minodora; Tomescu, M; Cristescu, Carmen; Voicu, Mirela; Citu, Ioana Mihaela; Cochera, F.; Gheorghiu, Cristina; Borcan, L.C.; Glarou, Z.M.A.; Tuduce, P.; Pascu, F; Mavrea, Adelina; Voicu, Adrian; Petrescu, Lucian

doi:10.1093/eurheartj/ehx502.p2637

Cited by 2 publications

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“…[19][20][21] In addition, there are studies on its potential superiority to CRP as a biomarker of cardiovascular disease due to its rapid response and ability to reflect vascular inflammation. 9,22,23 In a study conducted with childhood-onset systemic lupus erythematosus patients, it was found that serum PTX3 levels significantly increased in the presence of vasculitis, and it was reported that serum PTX3 levels could be useful in detecting subclinical vascular involvement. 24 In another study, serum PTX3 levels were found to be higher in patients with juvenile scleroderma than healthy controls, but there was no correlation with vascular complications.…”

Section: Discussionmentioning

confidence: 99%

Pentraxin 3 levels and correlation with disease severity in patients with acute rheumatic fever

et al. 2021

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Objectives: This study aims to investigate serum pentraxin 3 (PTX3) levels during acute episode of acute rheumatic fever (ARF) and their relationship with disease severity. Patients and methods: The prospective study was conducted between January 2015 and December 2018 and included 52 ARF patients (22 girls, 30 boys, mean age 10.7±2.1 years; range, 5 to 16 years) experiencing an acute episode and 22 healthy children (13 girls, 9 boys, mean age 10.3±3.8 years; range, 5 to 16 years). ARF patients were classified into three groups based on the clinical course: isolated arthritis (n=17), mild carditis (n=19), and moderate/severe carditis (n=16). Blood samples were collected from all patients before treatment and from the healthy children in the control group to measure PTX3 levels. PTX3 was measured using sandwich enzyme-linked immunosorbent assay method. Results: Plasma PTX3 levels were significantly higher in ARF group compared to the control group (4.7±5.2 and 1.2±1.7 ng/mL, p<0.001). Subgroup analysis of serum PTX3 levels in ARF patients with isolated arthritis, mild carditis, and moderate/severe carditis (3.2±3.1 ng/mL, 4.3±5 ng/mL, and 6.7±6.6 ng/mL, respectively) showed that serum PTX3 was significantly higher in the moderate/severe carditis group compared to the other groups (p<0.05). Analysis of echocardiographic data showed that serum PTX3 was positively correlated with left ventricular end-diastolic diameter, left atrial diameters, and mitral A velocity and negatively correlated with E/A ratio (p<0.05; r=0.231, 0.402, 0.562, -0.586, respectively). Conclusion: High PTX3 level during an acute episode of ARF may help predict the clinical course and the severity of accompanying carditis. However, prospective studies with larger sample sizes are needed.

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Section: Discussionmentioning

confidence: 99%

Pentraxin 3 levels and correlation with disease severity in patients with acute rheumatic fever

et al. 2021

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“…However, in contrast to CRP, it is produced locally in the inflamed tissue and in neutrophils [7]. There are indications that PTX3 may be superior to CRP as a biomarker of atherosclerotic cardiovascular diseases (CVD) (including acute coronary syndromes), possibly due to its ability to reflect vascular inflammation and due to the speed of its response [8–10]. Interestingly, the role of PTX3 in CVD may be protective, and PTX3 may represent a relevant therapeutic target [11,12].…”

Section: Introductionmentioning

confidence: 99%

Inflammatory cell infiltrates, hypoxia, vascularization, pentraxin 3 and osteoprotegerin in abdominal aortic aneurysms – A quantitative histological study

Blassová¹,

Tonar²,

Tomášek³

et al. 2019

PLoS ONE

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Information about the tissue characteristics of abdominal aortic aneurysms (AAAs), some of which may be reflected in the serum, can help to elucidate AAA pathogenesis and identify new AAA biomarkers. This information would be beneficial not only for diagnostics and follow-up but also for potential therapeutic intervention. Therefore, the aim of our study was to compare the expression of structural proteins, immune factors (T and B lymphocytes, macrophages, neutrophils and pentraxin 3 (PTX3)), osteoprotegerin (OPG), microvessels and hypoxic cells in AAA and nonaneurysmal aortic walls. We examined specimens collected during surgery for AAA repair (n = 39) and from the abdominal aortas of kidney donors without AAA (n = 8). Using histochemical and immunohistochemical methods, we quantified the areas positive for smooth muscle actin, desmin, elastin, collagen, OPG, CD3, CD20, MAC387, myeloperoxidase, PTX3, and hypoxia-inducible factor 1-alpha and the density of CD31-positive microvessels. AAA samples contained significantly less actin, desmin, elastin and OPG, more collagen, macrophages, neutrophils, T lymphocytes, B lymphocytes, hypoxic cells and PTX3, and a greater density of vasa vasorum (VV) than those in non-AAA samples. Hypoxia positively correlated with actin and negatively correlated with collagen. Microvascular density was related to inflammatory cell infiltrates, hypoxia, PTX3 expression and AAA diameter. The lower OPG expression in AAAs supports the notion of its protective role in AAA remodeling. AAA contained altered amounts of structural proteins, implying reduced vascular elasticity. PTX3 was upregulated in AAA and colocalized with inflammatory infiltrates. This evidence supports further evaluation of PTX3 as a candidate marker of AAA. The presence of aortic hypoxia, despite hypervascularization, suggests that hypoxia-induced neoangiogenesis may play a role in AAA pathogenesis. VV angiogenesis of the AAA wall increases its vulnerability.

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P2637ACE inhibitors and ARBs decrease more powerful the PTX-3 plasma levels of hypertensive patients with endothelial dysfunction compared with other anti-hypertensive drugs, in a chronic treatment

Cited by 2 publications

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Pentraxin 3 levels and correlation with disease severity in patients with acute rheumatic fever

Pentraxin 3 levels and correlation with disease severity in patients with acute rheumatic fever

Inflammatory cell infiltrates, hypoxia, vascularization, pentraxin 3 and osteoprotegerin in abdominal aortic aneurysms – A quantitative histological study

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