P26-14 Influence of anodal transcranial direct current stimulation on pain perception threshold in healthy volunteers

Maeoka, Hiroshi; Matsuo, Atsushi; Hiyamizu, Makoto; Morioka, Shigefumi

doi:10.1016/s1388-2457(10)61063-2

Cited by 1 publication

(2 citation statements)

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“…of continuous stimulation at an intensity of 2 mA. The stimulation intensity and duration is in line with previous studies showing somatosensory modulation using tDCS [2,15,[16][17][18][19][24][25][26][27]. Electrode impedances were continuously monitored and the device automatically shut off, if the impedance exceeded 15 kΩ.…”

Section: Transcranial Direct Current Stimulationsupporting

confidence: 69%

“…To date, there is no general consensus on which configuration of tDCS produces the most effective analgesic effect so attempting to identify new promising stimulation parameters is necessary [13]. Currently the most utilized tDCS configurations are anodal tDCS (a-tDCS) of primary motor cortex (M1) with the cathode placed over the contralateral supraorbital area (SO), which has been shown to significantly reduce pain perception [2,[14][15][16][17]. Cathodal tDCS (c-tDCS) of the primary somatosensory cortex (S1) with the anode placed over SO has likewise shown to significantly reduce pain perception [17][18][19].…”

Section: Introductionmentioning

confidence: 99%

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Neuromodulation of somatosensory pain thresholds of the neck musculature using a novel transcranial direct current stimulation montage: a randomized double-blind, sham controlled study

Kold

Kragh

Graven-Nielsen

et al. 2022

Scandinavian Journal of Pain

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Objectives Anodal transcranial direct current stimulation (tDCS) of primary motor cortex (M1) and cathodal of the primary sensory cortex (S1) have previously shown to modulate the sensory thresholds when administered with the reference electrode located over the contralateral supraorbital area (SO). Combining the two stimulation paradigms into one with simultaneous stimulation of the two brain areas (M1 + S1 − tDCS) may result in a synergistic effect inducing a prominent neuromodulation, noticeable in the pain thresholds. The aim of this study is to assess the efficacy of the novel M1 + S1 − tDCS montage compared to sham-stimulation in modulating the pain thresholds in healthy adults. Methods Thirty-nine (20 males) subjects were randomly assigned to either receiving 20 min. active M1 + S1 − tDCS or sham tDCS in a double-blinded single session study. Thermal and mechanical pain thresholds were assessed before and after the intervention. Results There were no significant differences in the pain thresholds within either group, or between the M1 + S1 − tDCS group and the Sham-tDCS group (p>0.05), indicating that the intervention was ineffective in inducing a neuromodulation of the somatosensory system. Conclusions Experimental investigations of novel tDCS electrode montages, that are scientifically based on existing studies or computational modelling, are essential to establish better tDCS protocols. Here simultaneous transcranial direct current stimulation of the primary motor cortex and primary sensory cortex showed no effect on the pain thresholds of the neck musculature in healthy subjects. This tDCS montage may have been ineffective due to how the electrical field reaches the targeted neurons, or may have been limited by the design of a single tDCS administration. The study adds to the existing literature of the studies investigating effects of new tDCS montages with the aim of establishing novel non-invasive brain stimulation interventions for chronic neck pain rehabilitation. North Denmark Region Committee on Health Research Ethics (VN-20180085) ClinicalTrials.gov (NCT04658485).

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