P254 Mucormycosis in hematological and oncological patients in Saint-Petersburg, Russia

Климко, Н Н; Хостелиди, С Н; Popova, M.; Волкова, А. Г.; Kolbin, A. S.; Boychenko, E. G.; Климович, А В; Белогурова, М. Б.; Подольцева, Э. И.; Medvedeva, Nadezhda; Zjuzgin, I.; Богомолова, Т С; Zubarovskaya, Ludmila; Afanasyev, B.; Vasilyeva, N. V.

doi:10.1016/s0924-8579(13)70495-3

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2014

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“…the survival rate of haematological patients with mucormycosis was 13%. According to the data of our register, the 12‐week survival rate for oncohaematological patients after treatment in 2011 was 27%, in 2012 it was 37% and in 2013 50% …”

Section: Discussionmentioning

confidence: 96%

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Mucormycosis in haematological patients: case report and results of prospective study in Saint Petersburg, Russia

Климко

Хостелиди

Волкова

et al. 2014

Mycoses

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SummaryWe prospectively observed 36 haematological patients with mucormycosis from nine hospitals of St. Petersburg during 2004-2013. The most frequent underlying diseases were acute leukaemia (64%), and main risk factors were prolonged neutropenia (92%) and lymphocytopenia (86%). In 50% of the patients, mucormycosis was diagnosed 1-65 days after invasive aspergillosis. Main clinical form of mucormycosis was pulmonary (64%), while two or more organ involvement was noted in 50% of the cases. The most frequent aetiological agents of mucormycosis were Rhizopus spp. (48%). Twelve-week survival rate was 50%. Combination therapy (echinocandins + amphotericin B forms) and recovery from the underlying disease significantly improved the survival rate.

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Section: Discussionmentioning

confidence: 96%

“…According to the data of our register, the 12-week survival rate for oncohaematological patients after treatment in 2011 was 27%, in 2012 it was 37% and in 2013 50%. 14,15…”

Section: Discussionmentioning

confidence: 99%