P245 Neutrophil to lymphocyte ratio predicts lymph node metastasis in triple negative breast cancer

Philip, Anil K.; Pavithran, K.; Jose, Wesley; Wesley, Johnna D.; Renjini, P.; Vijaykumar, D K; Dinesh, M; Annie, J.; Seethalakshmi, N.; Smitha, N V

doi:10.1016/s0960-9776(15)70277-8

Cited by 5 publications

(5 citation statements)

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“…Most previous studies have focused on the impact of the number and proportion of positive lymph nodes on patient survival [25,26]. Usually, LNR is regarded having certain value in predicting the prognosis of ovarian cancer, breast cancer, pancreatic cancer, and other malignancies [27][28][29][30][31][32][33]. In this study, the binary regression curve of the relationship between lymph node examination and survival time strongly suggests that increasing the number of lymph node examinations within a modest range may improve survival time with the same LNR and improve vital status with increased LNR.…”

Section: Discussionmentioning

confidence: 99%

Clinical gynecological practice analysis of lymphadenectomy for primary advanced ovarian serous cystadenocarcinoma based on the SEER database

Wang,

Zhang,

Liu

et al. 2023

Preprint

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Purpose Given the large number of patients with primary advanced ovarian serous cystadenocarcinoma (OSC) undergoing lymphadenectomy, it is necessary to explore the intrinsic significance of this procedure to improve the quality of precision medicine. Methods SEER database, epidemiological analysis, continuous landmark analysis, principal component analysis, COX regression and matrix analysis were performed to explore the weight changes of treatment, long-term effects, specific risk factors, and the significance of lymph node examination, positive lymph node count and ratio (LNR) for patients. Results Of the total 8673 patients who underwent debulking surgery, approximately 46.5% underwent additional lymphadenectomy. Through PCA, we found that FIGO/M staging, residual tumor volume/size, T/N staging, age and grade were extremely important risk factors for patients. Furthermore, Cox regression analysis showed that N, histology, residual tumor volume, systemic/surgery sequence, laterality, and marital status influenced the prognostic impact of lymphadenectomy compared with self-control. The LOESS fitting curve showed that when the number of examinations > 40, the beneficial effect of lymph nodes examination on survival time began to diminish in the survivor group, while showed a downward trend in the death cases. Additionally, LNR was found to be significantly associated with survival time and vital status, while lymph node examination was only significantly associated with survival time. Finally, residual foci size was found to be significantly associated with LNR and lymph node examination, but not with positive lymph nodes. Conclusions A detailed assessment of lymphadenectomy may have implications for clinical gynecologic practices and precision medicine.

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Section: Discussionmentioning

confidence: 99%

Clinical gynecological practice analysis of lymphadenectomy for primary advanced ovarian serous cystadenocarcinoma based on the SEER database

Wang,

Zhang,

Liu

et al. 2023

Preprint

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“…In univariate analysis we found an association of neutrophils for LN metastasis, but in multivariate logistic regression we found no predictive value for neutrophils, monocytes and lymphocytes. Although many studies have reported the predictive value of NLR for LN metastasis [24,25] , a report demonstrates that tumor-associated neutrophils in ltrating the tumor microenvironment, rather than circulating NLR, is an independent prognostic factor for LN metastasis of early GC. This suggests that neutrophils are associated with tumor progression.…”

Section: Discussionmentioning

confidence: 99%

Preoperatively predicting the lymph node metastasis and prognosis for gastric cancer patients

Wang,

Dong

et al. 2023

Preprint

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The preoperative distinguishment of lymph nodes (LN) with metastasis plays a pivotal role in guiding the surgical extension for gastric cancer (GC). We aim to identify the preparative risk factors for LN metastasis in GC patients. We retrospectively reviewed 424 patients who underwent radical GC resection in our medical center between Jan 2011 and Dec 2018. Multivariate logistic regression was employed to identify risk factors for LN metastasis, while multivariate COX regression was utilized to evaluate prognostic factors. 245 out of 424 people were identified with LN metastases. In multivariate analysis, low levels of albumin and prealbumin, as well as high levels of CEA, CA199, and platelets, were found to be significantly associated with LN metastasis in patients with GC. In survival analysis, older age, larger tumors, higher levels of D-dimer and CA199, advanced staging, lower prealbumin levels, and absence of adjuvant chemotherapy was discovered to be associated with a poorer prognosis in patients with GC. In conclusion, our results demonstrated that preoperative prealbumin-bound tumor markers can effectively predict LN metastasis in GC. Additionally, prealbumin was found to possess prognostic value as well.

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“…C-RP (c-reactive protein) was detected by immunoturbidimetry ( 16 ). NEUT% (percentage of neutrophils) and LYMPH% (percentage of percentage) were calculated by a calculation method ( 17 ).…”

Section: Methodsmentioning

confidence: 99%

Immunogenicity of Inactivated SARS-CoV-2 Vaccines in Patients With Rheumatoid Arthritis: A Case Series

Zhao

Shen

Zhu

et al. 2022

Front. Public Health

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ObjectivesAttenuated humoral response to mRNA SARS-CoV-2 vaccines has been reported in some patients with autoimmune disease, e.g., rheumatoid arthritis (RA). However, data of immune responses to inactivated SARS-CoV-2 vaccine in the RA population are still unknown. Herein, the safety and immunogenicity of inactivated SARS-CoV-2 vaccines in RA patients were analyzed.MethodsSeventy five RA patients and 26 healthy controls (HC) were respectively recruited from Yunnan Provincial Hospital of Traditional Chinese Medicine and the community in Kunming city. Neutralizing Antibody (NAb) Test ELISA kit was used to measure the percentage of inhibition. AKA (anti-keratin antibody) positivity was detected using indirect immunofluorescence. Rheumatoid factor (RF)-IgA was detected by ELISA. RF-IgG, RF-IgM, and anti-cyclic citrullinated peptide (CCP) antibodies were measured by chemiluminescence. ESR (erythrocyte sedimentation rate) was detected by ESR analyzer. C-RP (c-reactive protein) was detected by immunoturbidimetry. NEUT% (percentage of neutrophils) and LYMPH% (percentage of percentage) were calculated by a calculation method.ResultsCompared with the HC group, the percentage of inhibition was significantly lower in RA patients receiving two doses of vaccines. Vaccines-induced percentage of inhibition was the lowest in RA patients who had not been vaccinated. In total 80.77% of the HC group had a percentage of inhibition ≧20%, compared with 45.24% of vaccinated RA patients and 6.06% of unvaccinated RA patients. Spearman correlation analysis revealed that antibody responses to SARS-CoV-2 did not differ between RA patients according to their age and disease duration. Furthermore, the results showed that no correlation was found between the percentage of inhibition and indices for RA, including RF-IgA, IgG, IgM; anti-CCP antibody; ESR; C-RP; NEUT% and LYMPH%.ConclusionOur study showed inactivated vaccine-induced SARS-COV-2 antibody responses differ in RA patients and healthy subjects, emphasizing the importance of a third or fourth vaccination in RA patients.

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P245 Neutrophil to lymphocyte ratio predicts lymph node metastasis in triple negative breast cancer

Cited by 5 publications

References 0 publications

Clinical gynecological practice analysis of lymphadenectomy for primary advanced ovarian serous cystadenocarcinoma based on the SEER database

Clinical gynecological practice analysis of lymphadenectomy for primary advanced ovarian serous cystadenocarcinoma based on the SEER database

Preoperatively predicting the lymph node metastasis and prognosis for gastric cancer patients

Immunogenicity of Inactivated SARS-CoV-2 Vaccines in Patients With Rheumatoid Arthritis: A Case Series

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