P23 No association between VDR gene polymophisms (FoqI, TaqI and Apa1) and colorectal cancer in Romanian patients?

Toma, Mihai; Cimponeriu, Danut; Apostol, Pompilia; Stavarachi, Monica; Cojocaru, Manole; L, Beluşică; Lucian, G.

doi:10.1016/s1359-6349(08)70254-4

Cited by 9 publications

(12 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, we found cases with DI genotype to be 1.7 times and cases with II genotype 1.36 times more predisposed to CRC than that of DD genotype, overall risk of development of CRC for I allele was 1.61 times. These results were also similar to what has been already reported [18,33].…”

Section: Discussionsupporting

confidence: 93%

See 1 more Smart Citation

ACE Polymorphism in Colorectal Cancer Patients of Kashmiri Population – A Short Report

Sameer¹

2011

TOCOLCJ

View full text Add to dashboard Cite

Aims: The angiotensin-converting enzyme (ACE) gene in humans has an insertion-deletion (I/D) polymorphic state in intron 16 on chromosome 17q23. This polymorphism has been widely investigated in different cancers and has been implicated as the risk factor for the development of various cancers. To investigate the ACE I/D genotype frequency in CRC cases in Kashmiri population and to correlate it with the known clinicopathological characters of CRC cases. Methods: We designed a case control study, where 86 CRC cases were studied for ACE I/D polymorphism against 150 controls taken from general population. The polymorphisms of ACE gene were investigated using polymerase chain reaction for detection of an I/D polymorphism. Results: Among CRC (86) cases we found the frequency of ACE DD genotype to be 41.86 % (36/86), II 13.95% (12/86) and DI 44.2% (38/86). There was no significant association between the ACE I/D genotype with any of the known clinicopathological characters. Conclusion: The ACE I/D polymorphism is not a significant risk factor in the CRC carcinogenesis in our population.

show abstract

Section: Discussionsupporting

confidence: 93%

“…However statistically there was no significant association between the ACE I/D polymorphism with the CRC cases. These results were similar to one of the study where no relation was found between the ACE I/D polymorphism and the risk of CRC development [33,34].…”

Section: Discussionsupporting

confidence: 91%

ACE Polymorphism in Colorectal Cancer Patients of Kashmiri Population – A Short Report

Sameer¹

2011

TOCOLCJ

View full text Add to dashboard Cite

show abstract

“…In addition, there are several studies investigating the association between ACE gene polymorphism and risk of other cancers, such as gastric cancer [31][32][33][34], colorectal cancer [21,[35][36][37], lung cancer [21,38,39], and prostate cancer [21,[40][41][42]. The results have also been inconsistent.…”

Section: Discussionmentioning

confidence: 99%

Association between polymorphisms of the renin–angiotensin system genes and breast cancer risk: a meta-analysis

Zeng

Liu

et al. 2011

Breast Cancer Res Treat

View full text Add to dashboard Cite

The renin-angiotensin system (RAS) has been considered to be implicated in the development of breast cancer. However, the results are inconsistent. In this study, we conducted a meta-analysis to assess the association between four polymorphisms, including angiotensin I-converting enzyme (ACE) I/D and A240T, angiotensin II type 1 receptor (AGTR1) A1166C and angiotensinogen (AGT) M235T polymorphisms, and breast cancer risk. Published literature from PubMed, ISI web of science, and Embase databases were retrieved. All studies evaluating the association between ACE I/D, ACE A240T, AGTR1 A1166C, or AGT M235T polymorphism and breast cancer risk were included. Pooled odds ratio (OR) with 95% confidence interval (CI) was calculated using fixed- or random-effects model. Ten studies (1,650 cases and 9,283 controls) on ACE I/D polymorphism, six studies (1,316 cases and 2,632 controls) on ACE A240T polymorphism, three studies (235 cases and 601 controls) on AGTR1 A1166C polymorphism, and two studies (273 cases and 3,547 controls) on AGT M235T polymorphism were included. Overall, the meta-analysis showed no significant association between I/D or A240T polymorphism and breast cancer risk in either genetic model. Further subgroup analysis by ethnicity also revealed non-significant association in Caucasian or Asian populations except for Africans (the statistically significant association for ACE I/D or A240T polymorphism in Africans derived from only one study). A marginally significant association was observed for AGTR1 A1166C polymorphism in Caucasians (CC vs. AA: OR = 0.31, 95% CI 0.10-0.99). In addition, there was a significant association between AGT M235T polymorphism and breast cancer risk in Caucasians (OR = 1.45, 95% CI 1.12-1.88). The present meta-analysis suggested that ACE I/D and A240T polymorphisms might not be a good predictor of breast cancer risk, while AGTR1 A1166C and AGT M235T polymorphisms might be implicated in the pathogenesis of breast cancer. Given the limited sample size, the findings warrant further investigation.

show abstract

“…ACE activity is genetically regulated due to the insertion or deletion in the intron 16 of its gene, suggesting that ACE genotype is one of the crucial indicator in disease progression . Genetic polymorphisms in ACE gene and their relation to the incidence and progression of a various cancers were reported . The association between ACE gene polymorphism and the risk of lung cancer was also documented …”

Section: Introductionmentioning

confidence: 98%

Association of eNOS and ACE gene polymorphisms and plasma nitric oxide with risk of non‐small cell lung cancer in South India

Peddireddy

Badabagni

Gundimeda

et al. 2016

Clinical Respiratory J

View full text Add to dashboard Cite

show abstract

P23 No association between VDR gene polymophisms (FoqI, TaqI and Apa1) and colorectal cancer in Romanian patients?

Cited by 9 publications

References 0 publications

ACE Polymorphism in Colorectal Cancer Patients of Kashmiri Population – A Short Report

ACE Polymorphism in Colorectal Cancer Patients of Kashmiri Population – A Short Report

Association between polymorphisms of the renin–angiotensin system genes and breast cancer risk: a meta-analysis

Association of eNOS and ACE gene polymorphisms and plasma nitric oxide with risk of non‐small cell lung cancer in South India

Contact Info

Product

Resources

About