P229 Prevalence of macrolide and tetracycline resistant Treponema pallidum strains in syphilis cases, Lima and Pucallpa, Peru

Abstract

likely to use a condom than those in CNB (14.1% vs 5.5%, [age adjusted] AOR=0.32, 95%CI:0.18-0.56). In URB, condom use was associated with being male (16.7% vs 12.2% female, [age/region adjusted] AOR=1.47, 95%CI:1.12-1.94) and weakly associated with being older (16.5% among 17-19y vs 12.9% among 14-16y, AOR=1.27, 95% CI: 0.97-1.68, p=0.08). In CNB, condom use was associated with being female (10.5% vs 1.7% male, AOR=0.16, 95% CI: 0.04-0.58). Among URB participants, condom use was associated with sexual activity within the previous month (21.0% vs 4.4% non-recent activity, AOR=2.26, 95%CI:1.37-3.74). In univariable analysis, participants who reported sexual debut at 15y (17.9%) were more likely to report condom use than <15y (17.9%, OR=1.24, 95%CI: 0.95-1.62, p=0.08). Conclusions Reported condom use at last sexual encounter was low among adolescents in URB and CNB schools, particularly among adolescents of both sexes in CNB. Younger adolescents, those with a lower age of sexual debut, and especially females in URB and males in CNB, require targeted interventions to increase condom use at all encounters.

Fascinating Molecular and Immune Escape Mechanisms in the Treatment of STIs (Syphilis, Gonorrhea, Chlamydia, and Herpes Simplex)

“…A recent study on 25 positive T. pallidum DNA samples from active-syphilis patients found an 88% frequency of macrolide-resistance mutations, but no resistance to tetracyclines, suggesting that macrolides should be avoided in syphilis guidelines [ 75 ]. Additionally, a 2020 study comprising 146 French patients with early syphilis found an 85% resistance to macrolides, but no point mutations for doxycycline resistance and proved the absence of genomic resistance to tetracyclines [ 76 ].…”