P214 Persistance à long terme des anticorps anti-GAD et anti-IA-2 au cours du diabète de type 1 (DT1)

Progression of Autoantibodies Anti-Gad and Anti-IA2 in Type 1A Diabetics Aged 5 to 21 Years in Côte d’Ivoire

“…The rebound of anti-GAD autoantibodies observed at the 7 th year of diabetes and at the 9 th year for anti-IA2 is thought to be due to the persistence of the humoral immune response against the islet cells of the Langherans of the pancreas. Indeed, according to Wilmot-Roussel et al [8], anti-GAD and anti-IA2 autoantibodies persist during the type 1A diabetes. The body of T1D has secreted more anti-GAD and anti-IA2 autoantibodies to destroy the remaining β cell mass.…”

“…So, as some authors have shown, diabetes autoantibodies disappear with duration of diabetes, hence the disappearance in time of diabetes auto-antibodies in T1D in Côte d'Ivoire. This would be due to the destruction of β-cells [8]. It appears important to introduce in diabetes care in Côte d'Ivoire, the search for autoantibodies of diabetes, for a better classification and diabetes care.…”

“…Today, the diagnosis of type 1A diabetes is biological (fasting glucose greater than 1.26 g/l) and requires the search for autoantibodies of diabetes as a confirmation marker for autoimmune process [7]. According to some authors, these autoantibodies disappear with the duration of diabetes [8]. In Côte d'Ivoire, diabetes autoantibodies screening tests are not performed leading to a lack of the diagnosis of type 1A diabetes and a high rate of morbidity and early mortality in this type of Ivorian population.…”