P213 Molécules bioactives du lait maternel impliquées dans la maturité intestinale du nouveau-né grand prématuré

Garcia, Cyrielle; Brévaut-Malaty, Véronique; Millet, V.; Duan, R.D.; Gire, Catherine; Siméoni, Umberto; Gaudart, Jean; Bernard, Monique; Armand, M.

doi:10.1016/s0985-0562(13)70544-2

Cited by 1 publication

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“…[ 37 ] Therefore, the milk derived immune‐modulatory proteins become key antimicrobial and anti‐inflammatory components. [ 38 ] Many of these bioactive proteins are heat‐sensitive, [ 39 ] and the UHT treatment did cause losses of LF, IgG and IGF‐1 and antimicrobial activity (Figure 1 ), which are important for neutralizing bacteria and attenuating inflammatory responses, apoptosis and oxidative stress. [ 40 ] This is consistent with our previous study, where increased heat load compromised the inhibitory effects of milk proteins on pathogen growth.…”

Section: Discussionmentioning

confidence: 99%

Ultra‐High Temperature Treatment and Storage of Infant Formula Induces Dietary Protein Modifications, Gut Dysfunction, and Inflammation in Preterm Pigs

Sun

Akıllıoğlu

Aasmul‐Olsen

et al. 2022

Molecular Nutrition Food Res

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Scope: Ready-to-feed liquid infant formula is increasingly used for preterm infants when human milk is unavailable. These formulas are sterilized by ultra-high temperature treatment, but heating and storage may reduce bioactivity and increase formation of Maillard reaction products with potential negative consequences for immature newborns. Methods and results: Using preterm pigs as a model for sensitive newborn infants, the study tests the intestinal responses of feeding experimental liquid formula within 5 days. A pasteurized formula (PAST) with the same nutrient composition but less protein modifications serves as control to ultra-high temperature-treated formula without (UHT) and with prolonged storage (SUHT). Relative to PAST, UHT contains lower levels of lactoferrin and IgG. Additional storage (40 °C, 60 days, SUHT) reduces antimicrobial capacity and increases non-reducible protein aggregates and Maillard reaction products (up to 13-fold). Pigs fed SUHT have more diarrhea and show signs of intestinal inflammation (necrotizing enterocolitis) compared with pigs fed PAST and UHT. These clinical effects are accompanied by accumulation of Maillard reaction products, protein cross-links, and inflammatory responses in the gut. Conclusion: The results demonstrate that feeding UHT infant formulas, particularly after prolonged storage, adversely affects gut maturation and function in preterm pigs used as a model of preterm infants.

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