“…Transformation by tyrosine kinase fusion genes associated with human leukemia has been persistently linked to activation of Stat5. For instance, BCR/ABL expression due to Philadelphia chromosome translocation leads to Stat1 and Stat5 activation in chronic myelogenous leukemia (Carlesso et al, 1996;Chai et al, 1997;Ilaria and Van Etten, 1996;Shuai et al, 1996), and fusion of the JAK2 protein to the ets protein TEL causes Stat activation and myeloproliferative disease Lacronique et al, 1997;Schwaller et al, 1998). Stat5 is also activated by the TEL/PDGFbR, TEL/ABL and HIP1/PDGFbR oncogenic fusion proteins (Okuda et al, 1996;Ross and Gilliland, 1999;Sternberg et al, 1999).…”