P21/WAF1 is an independent survival prognostic factor for patients with hepatocellular carcinoma after resection

Kao, Jung Ta; Chuah, Seng Kee; Huang, Chao; Chen, Chao Long; Wang, Chih Chi; Hung, Chao Hung; Chen, Chien Hung; Wang, Jing Houng; Lu, Sheng; Lee, Chuan Mo; Changchien, Chi‐Sin; Hu, Tsung Hui

doi:10.1111/j.1478-3231.2007.01499.x

Cited by 31 publications

(29 citation statements)

References 39 publications

(62 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Both hSSB1 and p21 were mainly located in the nuclei of the cancer cells and were highly expressed in the HCC tissues (Figure 6a). This result was consistent with the majority of previous studies showing that the tumor cells of HCC exhibited positive nuclear staining of p21 (Qin et al, 1998;SchonigerHekele et al, 2005;Kao et al, 2007;Lee et al, 2009). However, some reports have showed cytoplasmic p21 staining in HCC (Tanaka et al, 2002;Lee and Helfman, 2004;Shiraki and Wagayama, 2006), and we also observed a weak cytoplasmic p21 staining in three cases (3%) of HCC tissues that were excluded in our statistical analyses in this report.…”

Section: Cdt2supporting

confidence: 82%

hSSB1 binds and protects p21 from ubiquitin-mediated degradation and positively correlates with p21 in human hepatocellular carcinomas

Feng

Zhang

et al. 2011

Oncogene

View full text Add to dashboard Cite

Section: Cdt2supporting

confidence: 82%

hSSB1 binds and protects p21 from ubiquitin-mediated degradation and positively correlates with p21 in human hepatocellular carcinomas

Feng

Zhang

et al. 2011

Oncogene

View full text Add to dashboard Cite

“…p21 was found to be down-regulated in HCC tissues, demonstrating its tumor suppressive function [25][26][27] . Kao et al [28] also reported that p21 expression was observed in 37% of HCC tissues, regardless of p53 expression, and was an independent survival good prognosis factor. While most of the reports show that p21 acts as a tumor suppressor, expression levels of p21 in liver cirrhosis have been reported to be correlated with the cumulative incidence of the occurrence HCC [29] and to be dominant in cytoplasm when histology became more undifferentiated [30] .…”

Section: Hcc Hbx and P21mentioning

confidence: 99%

Oncogenic role of p21 in hepatocarcinogenesis suggests a new treatment strategy

Ohkoshi

Yano

Matsuda

2015

WJG

View full text Add to dashboard Cite

A well-known tumor suppressor, p21, acts paradoxically by promoting tumor growth in some cellular conditions. These conflicting functions have been demonstrated in association with the HBx gene and in hepatocarcinogenesis. The molecular behavior of p21 depends on its subcellular localization. Nuclear p21 may inhibit cell proliferation and be proapoptotic, while cytoplasmic p21 may have oncogenic and anti-apoptotic functions. Because most typical tumor suppressive proteins also have different effects according to subcellular localization, elucidating the regulatory mechanisms underlying nucleo-cytoplasmic transport of these proteins would be significant and may lead to a new strategy for anti-hepatocellular carcinoma (HCC) therapy. Chromosome region maintenance 1 (CRM1) is a major nuclear export receptor involved in transport of tumor suppressors from nucleus to cytoplasm. Expression of CRM1 is enhanced in a variety of malignancies and in vitro studies have shown the efficacy of specific inhibition of CRM1 against cancer cell lines. Interestingly, interferon may keep p21 in the nucleus; this is one of the mechanisms of its anti-hepatocarcinogenic function. Here we review the oncogenic property of p21, which depends on its subcellular localization, and discuss the rationale underlying a new strategy for HCC treatment and prevention. Core tip: A well-known tumor suppressor, p21, can act paradoxically by promoting tumor growth, depending on its subcellular localization. Nuclear p21 may inhibit cell proliferation while cytoplasmic p21 may be associated with anti-apoptotic and oncogenic functions. REVIEW

show abstract

“…The cyclin kinase inhibitor p21/ WAF1 is a key molecule in the regulation of cellular proliferation. A recent study by Kao et al [55] indicated that the immunopositivity for P21/WAF1 in tumorous tissue correlated with patient survival and served as an independent prognostic factor of survival after surgical resection for HCC. In addition, many other prognostic markers have been retrospectively evaluated for HCC patients, but randomized prospective studies are needed to corroborate robust prognostic markers.…”

Section: Prognostic Markers Of Hccmentioning

confidence: 99%

Recent Advances in Tumor Markers of Human Hepatocellular Carcinoma

Yoon

2008

Intervirology

View full text Add to dashboard Cite

Hepatocellular carcinoma (HCC) is one of the most devastating malignancies in the world and is the third most common cause of cancer-related death in Korea. Because most HCC are accompanied by chronic liver disease that results from hepatitis B or C viruses, prognosis is still poor even after surgical resection of the tumor. Moreover, diagnosis of advanced HCC still leads to an extremely bleak prognosis. Earlier detection of HCC, therefore, could improve patient survival. Accordingly, the development of tumor markers that can detect HCC at even earlier stages is essential. The functions of tumor markers include prediction of prognosis or therapeutic response as well as diagnosis or screening of cancer. Possible candidate tumor markers may be quantitative alterations in DNA-, RNA- or protein-based molecules in tumorous conditions assessed by various technologies, e.g. serological assays, microarrays, mass spectrometry and proteomics. However, validation and clinical implementation is needed after the discovery of novel genes. An ideal tumor marker for HCC would be sensitive and specific enabling to differentiate it at an early stage from premalignant lesions like dysplastic nodules. In addition, the marker should be easily measurable, reproducible and minimally invasive. Although it is important to identify new biomarkers for HCC, the validation and cost-effectiveness of those markers as diagnostic or prognostic tools need confirmation in large-scale studies in clinical practice.

show abstract

P21/WAF1 is an independent survival prognostic factor for patients with hepatocellular carcinoma after resection

Cited by 31 publications

References 39 publications

hSSB1 binds and protects p21 from ubiquitin-mediated degradation and positively correlates with p21 in human hepatocellular carcinomas

hSSB1 binds and protects p21 from ubiquitin-mediated degradation and positively correlates with p21 in human hepatocellular carcinomas

Oncogenic role of p21 in hepatocarcinogenesis suggests a new treatment strategy

Recent Advances in Tumor Markers of Human Hepatocellular Carcinoma

Contact Info

Product

Resources

About