P21/ WAF1 and cyclin D1 variants and oral squamous cell carcinoma

Gomes, Carolina Cavaliéri; Drummond, Sérgio Neves; Guimarães, André Luiz Sena; Andrade, Carlos I.; Mesquita, Ricardo Alves; Gomez, Ricardo Santiago

doi:10.1111/j.1600-0714.2007.00604.x

Cited by 27 publications

(22 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Genetic and epigenetic factors are associated with a susceptibility to cancer development at a young age (4,37). Alternatively, genetic and epigenetics factors may play a stronger role than HPV-16/18 infection in the development of HNSSC at an early age (38)(39)(40)(41)(42). In the current study, we did not observe differences in survival associated with age, in agreement with previous studies (4,37).…”

Section: Discussionsupporting

confidence: 82%

HPV-16/18 detection does not affect the prognosis of head and neck squamous cell carcinoma in younger and older patients

et al. 2012

View full text Add to dashboard Cite

Abstract.Recently, high-risk human papillomavirus (HPV) has emerged as a possible agent associated with head and neck squamous cell carcinoma (HNSCC) in younger patients. Therefore, the purpose of the present study was to assess the effect of age on the distribution of HPV-16/18 in HNSCC, together with the impact of the virus on patient prognosis. A longitudinal prospective study was used adjusted for age, gender, TNM staging, smoking status and alcohol consumption. HPV was detected by PCR with consensus primers. Results showed there was no difference in the frequency of HPV-16/18 positivity when younger patients were compared to the older patients. No association was found among highrisk HPV positivity, gender, smoking habit and anatomical site. High-risk HPV was associated with advanced TNM in bivariate analyses; however, it did not impact on survival. Only TNM staging was associated with risk of mortality. Our study supports the theory that age does not affect the presence of HPV-16/18 in HNSCC and has no impact on patient prognosis. The incidence of HNSCC among patients under the age of 45 years is reportedly on the increase worldwide. The factors associated with HNSCC in younger adults are not well established. Findings of this study indicate that HPV-16/18 may not play a role in HNSCC patients under the age of 45 years.

show abstract

Section: Discussionsupporting

confidence: 82%

HPV-16/18 detection does not affect the prognosis of head and neck squamous cell carcinoma in younger and older patients

et al. 2012

View full text Add to dashboard Cite

show abstract

“…In addition, after excluding five studies (Catarino et al, 2006;Gomes et al, 2008;Tsai et al, 2011;Shih et al, 2012;Sabir et al, 2013) that significantly deviated from HWE, the results were not substantially altered, indicating statistically obvious robustness in our results (Table 3).…”

Section: Quantitative Synthesismentioning

confidence: 52%

“…However, 2 papers (Huang et al, 2006;Ye et al, 2008) were ruled out for the studies on premalignant lesion instead of cancer. As a result, 17 papers (Matthias et al, 1998;Zheng et al, 2001;Deng et al, 2002;Wong et al, 2003;Monteiro et al, 2004;Nishimoto et al, 2004;Holley et al, 2005;Catarino et al, 2006;Rydzanicz et al, 2006;Sathyan et al, 2006;Gomes et al, 2008;Marsit et al, 2008;Sui et al, 2009;Jelonek et al, 2010;Tsai et al, 2011;Shih et al, 2012;Sabir et al, 2013) comprising seventeen eligible studies with 3,761 cases and 3,834 controls for CCND1 G870A as well as three eligible studies (Sathyan et al, 2006;Tsai et al, 2011;Shih et al, 2012) with 943 cases and 935 controls for CCND1 G1722C were included. With regard to CCND1 G870A, seven studies (Matthias et al, 1998;Zheng et al, 2001;Monteiro et al, 2004;Holley et al, 2005;Catarino et al, 2006;Rydzanicz et al, 2006;Jelonek et al, 2010) were performed in Caucasians and seven (Deng et al, 2002;Wong et al, 2003;Sathyan et al, 2006;Sui et al, 2009;Tsai et al, 2011;Shih et al, 2012;Sabir et al, 2013) were conducted in Asians and three …”

Section: Study Characteristicsmentioning

confidence: 99%

“…With regard to CCND1 G870A, seven studies (Matthias et al, 1998;Zheng et al, 2001;Monteiro et al, 2004;Holley et al, 2005;Catarino et al, 2006;Rydzanicz et al, 2006;Jelonek et al, 2010) were performed in Caucasians and seven (Deng et al, 2002;Wong et al, 2003;Sathyan et al, 2006;Sui et al, 2009;Tsai et al, 2011;Shih et al, 2012;Sabir et al, 2013) were conducted in Asians and three (Nishimoto et al, 2004;Gomes et al, 2008;Marsit et al, 2008) for mixed population. Fifteen studies (Matthias et al, 1998;Deng et al, 2002;Wong et al, 2003;Monteiro et al, 2004;Nishimoto et al, 2004;Holley et al, 2005;Catarino et al, 2006;Rydzanicz et al, 2006;Sathyan et al, 2006;Gomes et al, 2008;Sui et al, 2009;Jelonek et al, 2010;Tsai et al, 2011;Shih et al, 2012;Sabir et al, 2013) were hospital-based and two studies (Zheng et DOI:http://dx.doi.org/10.7314/APJCP.2014.15.14.5645 Association of Cyclin D1 Variants with Head and Neck Cancer Susceptibility: Evidence from a Meta-analysis population-based. In addition, several studies had detailed genotype and allele frequencies under stratification of cancer site, gender, smoking status, alcohol drinking, T stage, histological differentiation and lymph nodes (Table 1 and Table 2).…”

Section: Study Characteristicsmentioning

confidence: 99%

See 1 more Smart Citation

Association of Cyclin D1 Variants with Head and Neck Cancer Susceptibility: Evidence from a Meta-analysis

Lin

Lian²,

Lin³

2014

Asian Pacific Journal of Cancer Prevention

View full text Add to dashboard Cite

“…Therefore, our study gives additional support that both smoking and aging are important factors involved in DNA methylation. In recent years, several studies have demonstrated that genetic polymorphisms are associated with susceptibility to, or protection from, cancer development (36,65,66). Until now, 13 polymorphisms were described in the coding region of gene DNMT3B according NCBI database, but the association between these genetic variations and cancer prognosis remains unclear.…”

Section: Discussionmentioning

confidence: 99%

Effect of age on the association between p16CDKN2A methylation and DNMT3B polymorphism in head and neck carcinoma and patient survival

Farias

Fraga²,

Oliveira³

et al. 2010

Int J Oncol

View full text Add to dashboard Cite

Abstract.De novo DNA methylation is a relevant epigenetic mechanism, which represses gene transcription and commonly inactivates tumor suppressor genes in carcinogenesis. A single nucleotide polymorphism of DNMT3B, C46359T (-149C→T) was reported to modulate individual's susceptibility to cancer. We investigated the role of this polymorphic variant regarding the methylation status of the p16CDKN2A gene in young and older patients with head and neck squamous cell carcinoma (HNCC) matched by the TNM staging system, together with its impact on patients survival. The results showed that the presence of the allele T of the polymorphism DNMT3B (-149C→T) was associated with advanced TNM staging and smoking habit, but no association was found between this polymorphisms and DNMT3B immunostaining. While p16CDKN2A methylation was significantly associated with smoking habit in older patients, this parameter was associated with family history of cancer in young patients. Moreover, in older patients the absence of p16CDKN2A promoter methylation had a negative impact on survival. In conclusion, nucleotide polymorphism of DNMT3B is not associated with methylation of p16CDKN2A gene in HNSCC. The association of p16CDKN2A gene methylation with smoking, family history of cancer and survival is dependent on age.

show abstract

P21/ WAF1 and cyclin D1 variants and oral squamous cell carcinoma

Abstract: The present study did not demonstrate a significant association between CCND1 and / or P21 / WAF1 genotypes and OSCC. However, P21 protein expression in OSCC tumours is affected by P21 / WAF1 genotype.

Cited by 27 publications

References 29 publications

HPV-16/18 detection does not affect the prognosis of head and neck squamous cell carcinoma in younger and older patients

HPV-16/18 detection does not affect the prognosis of head and neck squamous cell carcinoma in younger and older patients

Association of Cyclin D1 Variants with Head and Neck Cancer Susceptibility: Evidence from a Meta-analysis

Effect of age on the association between p16CDKN2A methylation and DNMT3B polymorphism in head and neck carcinoma and patient survival

Contact Info

Product

Resources

About