Abstract:Within the conduit, CSPGs incorporated into a nanofiber hydrogel form an interpenetrating network. Using a TMR rodent hindlimb model, we tested the effects of this device with and without CSPGs on neuroma formation.
RESULTS:The significant size mismatch at the coaptation site between the sciatic nerve and tibial branch to the lateral gastrocnemius muscle resulted in neuroma formation in the TMR group, while the use of the conduit resulted in tapered reinnervation of the sciatic nerve, demonstrating the effecti… Show more
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