P2‐437: Functional Changes and Peculiarities of Inducible No Synthase Expression in Dentate Gyrus of Aged Rats After Mild Stress

Ekova, Maria; Смирнов, А. В.; Tyurenkov, I. N.; Волотова, Е. В.; Grigoryeva, Natalya Vladimirovna; Горелик, Е В

doi:10.1016/j.jalz.2019.06.2844

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“…We observed a notable increase in the percentage of altered hyperchromic neurons in the hippocampus of old control rats compared with adult ones. Recent data confirm an increase in the relative number of hyperchromic neurons in aged rats in comparison with adult animals without any external exposure due to aging itself [ 18 ]. In our work, we counted mostly morphologically altered neurons of lesser size and polygonal, shrunken and wrinkled shape.…”

Section: Discussionmentioning

confidence: 84%

Morphofunctional Changes in Brain and Peripheral Blood in Adult and Aged Wistar Rats with AlCl3-Induced Neurodegeneration

Sentyabreva,

Miroshnichenko,

Melnikova

et al. 2023

Biomedicines

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Background: the general lifespan has been prolonged greatly during the past century, and the incidence of age-associated diseases, including neurodegenerative ones, has increased as well. However, modelling of age-related pathologies is mostly conducted on adult rodents. We studied morphofunctional changes in the brain and peripheral blood of adult Wistar rats in comparison with old Wistar rats to determine age-related physiological changes and differences in adaptive reactions to AlCl3 exposure. Methods: the work was performed on adult and old male Wistar rats. The animals consumed a 100 mg/kg solution of AlCl3 each day for 60 days. Morphological changes of neurons and microglia, mRNA expression levels of pro-inflammatory and anti-inflammatory cytokines, microglia activation markers, amyloid-related proteins, and hallmarks of cellular senescence, monocyte, and lymphocyte subpopulations in the peripheral blood were examined. Results: old rats showed increasing hyperchromic neurons in the hippocampus; activation of microglia; upregulation of pro-inflammatory cytokines and cellular senescence markers; downregulation of anti-inflammatory cytokines; and Hif-1a and a decrease in B-cells and monocyte in peripheral blood. Conclusion: compared to young animals, aged rats respond to aluminum exposure with a severe decline of most cells’ function and irreversible neuronal loss. Regarding all reported data, neurodegeneration modelling and investigating of factors capable of accelerating or preventing it should be performed in experimental work on aged animals.

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Section: Discussionmentioning

confidence: 84%