P2-299: Carboplatin/Gemzar combination in treatment NSCLC patients: age subgroup analysis

Abstract

Background: Platinum based doublet chemotherapy is considered standard but is often clinical inappropriate. Newer drugs as docetaxel and gemcitabine given as single agents in 1st-and 2nd-line have shown favorable toxicity and significant efficacy. It is assumed that sequencing of docetaxel and gemcitabine could be an equally effective alternative for palliation. Treatment: From 1998 to 2004 a total of 819 patients have been included in three studies (Figure ): two to identify an optimal single agent sequence; and one to compare sequential single agents to a platinum-free doublet.