P2–171: Clinical predictors of progression to Alzheimer's disease in amnestic mild cognitive impairment

Fleisher, Adam; Sowell, B. Brooke; Taylor, Catherine L.; Gamst, Anthony; Petersen, Ronald C.; Thal, Leon J.

doi:10.1016/j.jalz.2006.05.1009

Cited by 2 publications

(1 citation statement)

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“…Visuospatial function was assessed with a cube copying task [28] scored from 0 to 6 points [26]. Attention and speed were assessed using Trail Making Test Part A (TMT A) [29] and the Symbol Digit Modalities Test (SDMT) [30].…”

Section: Methodsmentioning

confidence: 99%

Cognitively normal women with Alzheimer’s disease proteinopathy show relative preservation of memory but not of hippocampal volume

et al. 2019

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BackgroundWe examined interactive effects of sex, diagnosis, and cerebrospinal fluid (CSF) amyloid beta/phosphorylated tau ratio (Aβ/P-tau) on verbal memory and hippocampal volumes.MethodsWe assessed 682 participants (350 women) from BioFINDER (250 cognitively normal [CN]; and 432 symptomatic: 186 subjective cognitive decline [SCD], 246 mild cognitive impairment [MCI]). General linear models evaluated effects of Alzheimer’s disease (AD) proteinopathy (CSF Aß/p-tau ratio), diagnosis, and sex on verbal memory (ADAS-cog 10-word recall), semantic fluency (animal naming fluency), visuospatial skills (cube copy), processing speed/attention functions (Symbol Digit Modalities Test and Trail Making Part A), and hippocampal volumes.ResultsAmyloid-positive (Aβ/P-tau+) CN women (women with preclinical AD) showed memory equivalent to amyloid-negative (Aβ/P-tau−) CN women. In contrast, Aβ/P-tau+ CN men (men with preclinical AD) showed poorer memory than Aβ/P-tau− CN men. Symptomatic groups showed no sex differences in effect of AD proteinopathy on memory. There was no interactive effect of sex, diagnosis, and Aβ/P-tau on other measures of cognition or on hippocampal volume.ConclusionsCN women show relatively preserved verbal memory, but not general cognitive reserve or preserved hippocampal volume in the presence of Aβ/P-tau+. Results have implications for diagnosing AD in women, and for clinical trials.

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Section: Methodsmentioning

confidence: 99%