P2-144 High-salt intake during pregnancy in ewes alters organ weights and aldosterone concentration in adult offspring

Tay, Sharon; Digby, S.N.; Pain, S. J.; Blache, Dominique; Revell, Dean

doi:10.1016/s0378-3782(07)70477-2

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“…Accumulating evidence from clinical and experimental investigations in the last two decades demonstrated that renal and cardiovascular diseases, including hypertension, could be programmed in fetal origins (Guyton et al 1972, Hoy et al 1999, Woods 2000, Barker 2002, do Carmo Pinho et al 2003, Logan 2006, Bagby 2007, Blache et al 2007, Tay et al 2007, 2012, Gluckman et al 2008). The present study provided new information on the influence of high salt intake during pregnancy on fetal local renal RAS development in relation to the long-term impacts on the offspring.…”

Section: Discussionmentioning

confidence: 99%

High-salt diets during pregnancy affected fetal and offspring renal renin–angiotensin system

Mao

Liu²,

Bo³

et al. 2013

Journal of Endocrinology

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Intrauterine environments are related to fetal renal development and postnatal health. Influence of salty diets during pregnancy on renal functions and renin–angiotensin system (RAS) was determined in the ovine fetuses and offspring. Pregnant ewes were fed high-salt diet (HSD) or normal-salt diet (NSD) for 2 months during middle-to-late gestation. Fetal renal functions, plasma hormones, and mRNA and protein expressions of the key elements of renal RAS were measured in the fetuses and offspring. Fetal renal excretion of sodium was increased while urine volume decreased in the HSD group. Fetal blood urea nitrogen was increased, while kidney weight:body weight ratio decreased in the HSD group. The altered ratio was also observed in the offspring aged 15 and 90 days. Maternal and fetal plasma antidiuretic hormone was elevated without changes in plasma renin activity and Ang I levels, while plasma Ang II was decreased. The key elements of local renal RAS, including angiotensinogen, angiotensin converting enzyme (ACE), ACE2, AT1, and AT2 receptor expression in both mRNA and protein, except renin, were altered following maternal high salt intake. The results suggest that high intake of salt during pregnancy affected fetal renal development associated with an altered expression of the renal key elements of RAS, some alterations of fetal origins remained after birth as possible risks in developing renal or cardiovascular diseases.

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