[P2–102]: The Puerto Rico Alzheimer Disease Initiative (Pradi): A Multisource Ascertainment Approach

Linkage Analysis in Caribbean Hispanic Families with Puerto Rican Ancestry Idenitfies an Alzheimer Disease Locus on chromosome 9

“…To begin addressing these issues, we focused on a Caribbean Hispanic Puerto Rican (CHI PR) population and selected multiplex AD families. CHI PRs have a high prevalence rate of AD (12.5%) that is higher than it was estimated in the general U.S. population (10.1%), but CHI PRs are underrepresented in AD genetic studies 9 . Moreover, the genetic make-up of CHI PRs is not homogenous; they are highly admixed, with average ancestry values of 69% European (EU), 17% African (AF), and 14% Native American (AI) 9 .…”

“…CHI PRs have a high prevalence rate of AD (12.5%) that is higher than it was estimated in the general U.S. population (10.1%), but CHI PRs are underrepresented in AD genetic studies 9 . Moreover, the genetic make-up of CHI PRs is not homogenous; they are highly admixed, with average ancestry values of 69% European (EU), 17% African (AF), and 14% Native American (AI) 9 . The ancestral heterogeneity in CHI PR population make it unique in the discovery of novel AD loci, as well as in the replication of findings from European-descent and African-descent populations.…”

“…Patients were evaluated to determine their AD clinical status based on the National Institute of Neurological and Communicative Disorders and Stroke-Alzheimer's Disease and Related Disorders Association criteria 10,11 . A detailed description of our ascertainment and clinical evaluation methods of the individuals have been previously described 9 . However briefly, cases were defined as individuals have a previous clinical diagnosis of AD, mild cognitive impairment (MCI), dementia, or show evidence of a memory disorder, and meet standard criteria for AD or MCI [10][11][12] .…”