P2.078 Drug Resistance of Mycobacterium Tuberculosis at Patients with Combination of Tuberculosis and the HIV Infection

Abstract

Results Over the study period, 1533 female patients were tested for TV using the rapid test, of which 539 (35.2%) were Black, with a median age of 28 years (range 6-82 years). The TV positivity rate based on the rapid test was 5.6% (86/1533), compared to 3.2% (54/1681) among those tested with WM. Among 77 unique female patients with TV infection, 467 (34.0%) were Black and had a median age of 28 years. Nearly half of infected women presented with a chief complaint of abdominal pain (49%); vaginal discharge was only reported by 10%. Among infected women, 55% had concomitant bacterial vaginosis (BV), and 16% were co-infected with gonorrhoea and/or chlamydia. Most infected women (84%) were prescribed metronidazole during the same ER visit. Purpose To estimate of drug resistances of (MBT) at patients with combination of tuberculosis and the HIV (TB+HIV). MBT excreting it has been identified at 67.7% TB+HIV cases, and in 53.2% cases baccilar TB have been revealed by culture. From them only at 19.9% of MBT were sensitive to antitubercular drugs, at others tests identified presence of resistance of various prevalence. Resistance to streptomycin (73.2%) and izoniasid 73.4% was more often, it is a little bit less -to rifampicin -than 63.3%, and ethambutol -41.2%. Among second line TB drugs the greatest resistance has been fixed to canamycin -36.7%, to other drugs of this group it did not exceed 20%. Conclusions Materials and MethodsThe proportion of patients with multi drug resistant MBT has determined in an interval of 80.6% of -65.3%; among patients with new cases of TB it was on the average 73.3%. Extremely drug resistant MBT (XDR) has registered among for the new cases within 7.9% -14.8%. Patients with XDR had expressed immune suppression and progressing of tuberculosis with development generalised forms even at use of ART. Lethal outcomes at them made 56.9%. Conclusion wide circulation of multi and extremely drug resistant MBT at patients with TB+HIV makes inefficient treatment at prescription of f standard TB schemes. Besides for these patients use of methods of fast identification of drug resistance is necessary. P2.080Background Appropriate and timely treatment for Neisseria gonorrhoeae infection is an essential clinical and public health action. Antimicrobial susceptibility testing (AST) predicts therapeutic failure and guides selection of appropriate treatment.Increasing antimicrobial resistance in N. gonorrhoeae prompted the publication of the global action plan by the World Health Organisation to control its spread. This document highlighted the lack of or use of different methodologies for AST making the inter-laboratories and international comparisons and monitoring difficult. Aims The aim of this study was to explore whether laboratories offered AST for N. gonorrhoeae and which methodologies were being used to detect resistance particularly to current recommended treatment. 196 respondents (95%) conducted AST for N. gonorrhoeae with 46% performing this daily. 147 respondents (75%) used British Society of...