P2‐023: Mild Cognitive Impairment With a High Risk of Progression to Alzheimer's Disease Dementia (Mci‐hr‐ad): Effect of Souvenaid® Treatment on Cognition and 18f‐fdg Pet Scans

Abstract

randomly divided into three groups which were A a singing group, B a reading group and C a control group. All participants underwent a series of neuropsychological tests as a baseline (t 0) assessment with the guidance of medical professionals, and subsequent tests were repeated at three months (t 1 ) and six months (t 2 ) periods for comparison. Results: For participants with mild AD, the WHO-UCLA AVLT immediate and delayed recall scores of Group A were significantly higher at t 1 compared with t 0 . The verbal fluency test scores were increased in Group A at t 1 and t 2 compared with t 0 , while there was also significant increase in Group B at t 1 but it did not show significant changes at t 2 . The NPI scores of Group A significantly decreased at t 1 and t 2 compared with t 0 . The caregiver distress score of Group A also significantly decreased at t 1 and t 2 compared with t 0 . For participants with moderate or severe AD, the caregiver distress score in NPI of Group A significantly decreased at both t 1 and t 2 compared with t 0 . There were no significant changes of the MMSE score and the BI during this study in all the groups. Conclusions: Music therapy is effective for enhancing memory and language ability of patients with mild AD, and can reduce the psychotic symptoms and caregiver distress of patients with mild, moderate or severe AD the severity of AD.