P2‐017: The Effectiveness of Action Observation Treatment (AOT) in Alzheimer's Disease: Benefit on Temporal Orientation and Visuo‐Prassic Abilities

Caffarra, Paolo; Perini, Marta; Reda, Valentina; Barocco, Federica; Michelini, Giovanni; Spallazzi, Marco; Gabriella, Di Santo Simona; Caltagirone, Carlo; Rozzini, Luca; Padovani, Alessandro; Buccino, Giovanni; Fulvia, Di Iulio; Camanini, Giuseppe; Gardini, Simona

doi:10.1016/j.jalz.2016.06.1221

Cited by 3 publications

(2 citation statements)

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“…The data analysis showed a significant improvement between test and retest in a naming action task. However, recently an intervention focused on MN in AD patients showed negative results (Caffarra et al, , oral communication at XI Sindem National Congress, Florence, Italy). If the MN network is already disturbed in the pre‐dementia phase, as suggested by Moretti’s () and Farina et al's () studies, AOT would result ineffective as a rehabilitation technique in moderate AD, and it should be rather performed in the MCI or at least in the early phase to achieve positive results.…”

Section: Mirror Neurons and Neurodegenerative Diseasesmentioning

confidence: 99%

Mirror neurons and their relationship with neurodegenerative disorders

Farina

Borgnis

Pozzo

2020

J of Neuroscience Research

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The finding of mirror neurons (MNs) has provided a biological substrate to a new concept of cognition, relating data on actions and perceptions not only to integrate perception in action planning and execution but also as a neural mechanism supporting a wide range of cognitive functions. Here we first summarize data on MN localization and role in primates, then we report findings in normal human subjects: functional magnetic resonance imaging and neurophysiological studies sustain that MNs have a role in motor learning and recognizing actions and intentions of others, and they also support an embodied view of language, empathy, and memory. Then, we detail the results of literature searching on MNs and embodied cognition in Parkinson's disease (PD), frontotemporal dementia (FTD)/amyotrophic lateral sclerosis (ALS), and in mild cognitive impairment (MCI)/Alzheimer's disease (AD). In PD the network of MN could be altered, but its hyperactivation might support motor and cognitive performances at least in early stages. In the ALS/FTD continuum, preliminary evidence points out to an involvement of the MN network, which could explain language and inter-subjectivity deficits shown in patients affected by these clinical entities. In the MCI/ AD spectrum, a few recent studies suggest a possible progressive involvement from posterior to anterior areas of the MN network, with the brain putting in place compensatory mechanisms in early stages. Reinterpreting neurodegenerative diseases at the light of the new views about brain organization stemming from the discovery of MN could help to better comprehend clinical manifestations and open new pathways to rehabilitation. K E Y W O R D S Alzheimer's disease, amyotrophic lateral sclerosis, embodied cognition, frontotemporal dementia, mirror neurons, Parkinson's disease | 1071 FARINA et Al.

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Section: Mirror Neurons and Neurodegenerative Diseasesmentioning

confidence: 99%

Mirror neurons and their relationship with neurodegenerative disorders

Farina

Borgnis

Pozzo

2020

J of Neuroscience Research

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“…For patients with neurological disorders, action observation (AO) and motor imagery (MI) can be useful and safe tools [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15]. Compared with either AO or MI applied alone, previous studies with healthy participants revealed a stronger effect when action observation is combined and simultaneously performed with motor imagery (AOMI) [16][17][18][19][20][21][22][23].…”

Section: Introductionmentioning

confidence: 99%

Influence of combined action observation and motor imagery of walking on lower limb reflex modulation in patients after stroke–preliminary results

2022

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Objective The combined use of action observation and motor imagery (AOMI) is a promising technique in neurorehabilitation that can be usefully applied in addition to conventional forms of therapy. Previous studies with healthy participants showed that the mere passive observation of walking results in a phase-dependent reflex modulation in the tibialis anterior muscle that resembles the pattern occurring when walking. In patients after stroke, a similar reflex modulation was found in several lower limb muscles during the real execution of walking, but responses were blunted. To clarify whether and how lower limb reflex responses are also modulated in such patients during the combined synchronous observation and imagery of walking, medium-latency cutaneous reflexes from the tibialis anterior muscle were measured. We compared the reflex responses of seven patients after stroke during the AOMI of walking from two different conditions: (a) elicited during the end stance phase and (b) during the end swing phase, both normalized to a baseline condition. Results So far, using the identical methodological set-up as in our study with healthy individuals, we could not find any noteworthy reflex response modulation. The study was registered with the German Clinical Trials Register (DRKS00028255). Trial registration : The study was registered with the German Clinical Trials Register: DRKS00028255.

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