P2.01-30 Hepatitis B Infection or Aminotransferase Increase Associate with Poor Outcome of Anti-PD-1 Monotherapy in Patients with Advanced NSCLC

Abstract

The 92 patients had air leakage at the time of transferring to intensive care unit or recovery room (postoperative air leakage: POAL). The log data of these 89 patients were analyzed retrospectively and We examined their characteristics using univariate and multivariate manners in logistic regression analysis. Result: The median age at the time of pulmonary resection in these 89 patients (72 men and 17 women) was 72 years (range, 40 to 86 years). The 75 patients (84%) had smoking history. The 17 patients (19%) had diabetes mellitus. The 49 patients (55%) had emphysema. Surgical procedures were a lobectomy in 71 patients, a segmentectomy in 4 patients, and a wedge resection in 14 patients. Fibrin glue was used during surgery in 45 patients (51%). The mean flow of POAL was 70.4 ml/min (range, 20.2-1267.9). The mean duration of air leakage was 60 hours (range, 9-257). In univariate analysis, diabetes mellitus (DM, p¼0.0284, OR; 3.450), use of fibrin glue (p¼0.0452, OR; 0.411), and POAL (p¼0.0101) were statistically significant. In the final multivariate model, DM (p¼0.0441) and flow of POAL (p¼0.0228) were independently associated with PAL. In ROC curve, considering less than 20% false positive rate, the optimal cutoff in patients with DM was 100ml/min (sensitivity; 67%, specificity; 82%). The optimal cutoff in patients without DM was 150ml/min (sensitivity; 53%, specificity; 84%). Conclusion: The POAL flow of 150ml/min or more in patients without DM and that of 100 ml/min or more in patients with DM will be likely to develop PAL with high probability. Pleurodesis may be considered earlier for this population.