p16<sup>INK4A</sup> positivity identifies endometrial surface papillary syncitial change as a regressive feature associated with desquamation

Nicolae, Alina; Preda, Ovidiu; Aneiros‐Fernández, José; Palacios, José; Biscuola, Michele; Nogales, Francisco F.

doi:10.1111/j.1365-2559.2011.03766.x

Cited by 5 publications

(3 citation statements)

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“…Some87 88 favour the possibility of a cellular change associated with endometrial regeneration, while others84 85 interpret it as a degenerative phenomenon secondary to the ischaemia that occurs during endometrial shedding. Its strong cytoplasmic and nuclear p16 INK4A positivity89 (figure 14) would support the latter. Others have considered it as a metaplastic1 or hyperplastic83 phenomenon.…”

Section: Epithelial Emcsmentioning

confidence: 72%

Endometrial metaplasias and reactive changes: a spectrum of altered differentiation

2010

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Endometrial metaplasias and changes (EMCs) are conditions frequently overlooked and misdiagnosed. The aim of this review is to update current issues and provide a classification with a practical clinicopathological approach. Hormonal or irritative stimuli are the main inducing factors of EMCs, although some metaplasias have a mutational origin. EMCs vary from reactive, degenerative lesions to those able to associate with malignancy or those having a preneoplastic potential. The most common types of EMCs are ciliated tubal metaplasia (CTM) and mucinous metaplasia (MM), which occur in simple and complex glands, and possibly these architectural changes hold the same prognostic significance as they do in hyperplastic endometrioid lesions. Immunohistochemically, CTM is positive for LhS28, bcl-2, PAX2 and p16

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Section: Epithelial Emcsmentioning

confidence: 72%

Endometrial metaplasias and reactive changes: a spectrum of altered differentiation

2010

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“…It may be accompanied by a small amount of active epithelial hyperplasia, cystic dilatation of the gland, intensive hyperplasia of the focal glands, abundant interstitial cells in some parts, moderate atypia, nuclear mitosis, or borderline changes, metaplasia of the fallopian tube, and atypical hyperplasia, which also bring great confusion for pathological examination [22][23][24] . At present, the immunohistochemical studies on PEM mostly suggest ER(+), PR(+), and Vinmentin(++), as previously mentioned [26,29] . Two immunohistochemical examinations of 7 cases in this group showed P16(+).…”

Section: Clinicopathological Featuresmentioning

confidence: 68%

Clinical study on 7 cases of polypoid endometriosis. PEM: a mimic of malignancy, the symptoms of adenomyosis, endometrial polyps and infertility can assist in diagnosis

Zheng¹,

Xu²,

chen³

et al. 2021

Preprint

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Objective: polypoid endometriosis (PEM) is a rare type of endometriosis (EMs), which is easy to be misdiagnosed. The purpose of this paper is to investigate the clinical features and diagnostic methods of PEM. Methods:The clinical data of 7 patients with PEM who were treated at Fujian Provincial Maternity and Children’s Hospital in China within July 2017 to December 2020 period were retrospectively analyzed, and their clinical characteristics, diagnosis, treatment and prognosis were summarized. Results: The age of onset was 31-41 (38.00 ± 1.72) years. There were 5 cases with adenomyosis, 4 cases with endometrial polyps and infertility. The clinical manifestations were diverse. Most of them were pelvic mass, compression symptoms and signs, dysmenorrhea and abnormal uterine bleeding, and three of them were similar to malignant tumors. The gross pathological features were cysts, endogenous or exogenous polypoid masses, which were all composed of endometrioid glands and stromal components, but more diverse than ordinary em. All the 7 patients were confirmed by operation and pathology. Conclusion: PEM is often complicated with adenomyosis, endometrial polyps and infertility. Pathological examination is the gold standard for diagnosis. Imaging examination is easy to be misdiagnosed. Abnormal increase of CA125 can assist in diagnosis.

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“…In the neoplastic context, p16 dysregulation can occur through a variety of mechanisms, but increased p16 expression could also reflect a senescence‐type cellular process, as has been suggested to occur in endometrial polyps . Epithelial staining in such cases could also reflect the higher incidence of epithelial metaplasia in polypoid lesions, as it is well‐recognized that metaplastic changes in the endometrium can be associated with increased p16 expression …”

Section: Discussionmentioning

confidence: 99%

Clinicopathological and immunohistological features of polypoid endometriosis

Stewart

Bharat

2015

Histopathology

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There are two main subgroups of PE. The majority of cases in this series showed similar histological features to NPE, but involved anatomical sites that facilitated exophytic or polypoid growth. The remaining PE cases resembled eutopic endometrial polyps histologically and immunophenotypically and they occurred in older patients. These findings suggest that such lesions are 'true' polyps sharing a pathogenetic relationship with similar lesions arising in the endometrium.

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p16^INK4A positivity identifies endometrial surface papillary syncitial change as a regressive feature associated with desquamation

Cited by 5 publications

References 10 publications

Endometrial metaplasias and reactive changes: a spectrum of altered differentiation

Endometrial metaplasias and reactive changes: a spectrum of altered differentiation

Clinical study on 7 cases of polypoid endometriosis. PEM: a mimic of malignancy, the symptoms of adenomyosis, endometrial polyps and infertility can assist in diagnosis

Clinicopathological and immunohistological features of polypoid endometriosis

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p16INK4A positivity identifies endometrial surface papillary syncitial change as a regressive feature associated with desquamation

Cited by 5 publications

References 10 publications

Endometrial metaplasias and reactive changes: a spectrum of altered differentiation

Endometrial metaplasias and reactive changes: a spectrum of altered differentiation

Clinical study on 7 cases of polypoid endometriosis. PEM: a mimic of malignancy, the symptoms of adenomyosis, endometrial polyps and infertility can assist in diagnosis

Clinicopathological and immunohistological features of polypoid endometriosis

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p16^INK4A positivity identifies endometrial surface papillary syncitial change as a regressive feature associated with desquamation