p16 hypermethylation: A biomarker for increased esophageal cancer susceptibility in high incidence region of North East India

Das, Mandakini; Saikia, Basanta; Sharma, Sandeep; Sekhon, Gaganpreet Singh; Mahanta, Jagadish; Phukan, Rup Kumar

doi:10.1007/s13277-014-2762-7

Cited by 18 publications

(12 citation statements)

References 32 publications

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“…Some genes like GSTP1 was related with ESCC in the South African population [ 40 ]; high CYP3A5 activity could increase esophageal cancer risk in Black Africans [ 41 ]. Genetic variants associated with ESCC in Chinese, Indians or other populations were reported [ 42 – 44 ]. Programmed death ligand-1 (PD-L1) was reported as a potential biomarker for the prognosis of ESCC, and the high expression indicated a poor prognosis [ 45 , 46 ].…”

Section: Discussionmentioning

confidence: 99%

Incidence and survival differences in esophageal cancer among ethnic groups in the United States

Chen

Ren

et al. 2017

Oncotarget

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ObjectivesThis study was performed to identify the differences in incidence, clinicopathological features, and survival in esophageal cancer among ethnic groups in the United States and to determine the reasons for the differences.ResultA total of 49,766 patients were included. Black and Asian groups had a higher proportion of squamous cell carcinoma (ESCC) (85.5% and 75.4%, respectively) and mid-esophagus tumor (43.2% and 37.7% respectively) than the non-Hispanic white and Hispanic white groups. The incidences of ESCC in all ethnic groups declined since 1973, especially in black males. At the same time, incidences of esophageal adenocarcinoma (EAC) dramatically increased in white males since 1973. And incidences of ESCC and EAC were the lowest and stable in Asian female. Multivariable models showed that patients who were male, or black, or had larger tumors, or positive lymph nodes had an increased risk of death from esophageal cancer, while patients with ESCC or diagnosed after 2005 or treated with surgery had a lower likelihood of death. For ESCC, the black patients had the lowest DSS, while for EAC there were no significant differences in DSS among the ethnic/racial groups.Materials and MethodFrom the Surveillance, Epidemiology, and End Results Program database, patients diagnosed with esophageal cancer from 1998-2013 were identified. Differences in incidences, clinicopathological features, treatments, and disease-specific survival (DSS) in four broad racial/ethnic groups were compared.ConclusionHistological type distribution between racial groups could be an important consideration in the incidence and the survival trend but other factors could also have an effect.

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Section: Discussionmentioning

confidence: 99%

Incidence and survival differences in esophageal cancer among ethnic groups in the United States

Chen

Ren

et al. 2017

Oncotarget

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“…This includes countries such as Australia, United Kingdom, United States of America and some Western European countries such as Finland, France and the Netherlands. The five-year survival of oesophageal patients ranges from 15 to 25% ( 5 – 7 ). Greater than 490,000 new cases of OC were reported in 2005 and the prevalence of oesophageal cancer (OC) is expected to increase by 14% while other types of cancers incidence are expected to decrease by 2025 ( 8 , 9 ).…”

Section: Introductionmentioning

confidence: 99%

A multinational review: Oesophageal cancer in low to middle‑income countries (Review)

et al. 2020

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Oesophageal cancer (OC) is an aggressive neoplasm that manifests in the gastrointestinal tract and is the result of numerous factors that can contribute to the development of the disease. These may include old age, nutritional deficiencies, oesophageal obstruction and food ingestion difficulties. Environmental factors serve a large role in increasing the risk of developing OC. Two factors that serve an increasing risk of developing OC are the use of tobacco and the consumption of alcohol. Genetic factors also exhibit a large effect on the risk of developing OC, for example, the causative genes in Black Africans differ from other races. OC is 3-4 times more common among men than women. OC has been previously reported in >450 000 individuals worldwide, and its incidence is increasing. The current review compares OC in low to middle-income countries with developed countries. The incidence of OC, particularly squamous cell carcinoma (SCC) is high in low and middle-income countries. In developed countries, the incidence of SCC is low compared with adenocarcinoma. The majority of OC cases are diagnosed in the late stages of the disease, leading to high mortality rates. The current review aimed to discuss factors that contribute to the development of this disease in different geographical areas and genetic mechanisms governing these findings. The current review also aims to discuss the preventative treatment options for the disease, and also discusses the diagnosis and surveillance in five LMICs, including South Africa, China, Tanzania, India and Brazil. Contents 1. Introduction 2. Methods 3. Oesophageal cancer risk Factors 4. Epidemiology of oesophageal cancer 5. Oesophageal cancer in low to middle countries compared to developed countries 6. Molecular epidemiology of oesophageal cancer 7. Diagnosis and prognosis of oesophageal cancer 8. Oesophageal cancer treatment 9. Conclusions

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“…23 Previous reports have revealed that p16 gene is frequently found to be methylated in a number of cancers. [24][25][26] Similarly, p53 alterations, including p53 mutations and single-nucleotide polymorphism (SNP) in codon 72 of p53 gene, have been reported to be associated with esophageal cancer development. [27][28][29] The SNP at position 72 (R72P) of the p53 protein encodes either an arginine or proline, which can alter the apoptotic activity of p53 via transcriptional and non-transcriptional mechanisms.…”

Section: Introductionmentioning

confidence: 99%

p16 gene silencing along with p53 single-nucleotide polymorphism and risk of esophageal cancer in Northeast India

et al. 2017

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The high incidence of esophageal cancer in Northeast India and the unique ethnic background and dietary habits provide a great opportunity to study the molecular genetics behind esophageal squamous cell carcinoma in this part of the region. We hypothesized that in addition to currently known environmental risk factors for esophageal cancer, genetic and epigenetic factors are also involved in esophageal carcinogenesis in Northeast India. Therefore, in this study, we explored the possible association between the two important G1 cell cycle regulatory genes p16 and p53 and environmental risk factors and risk of esophageal carcinogenesis. A total of 100 newly diagnosed esophageal cancer cases along with equal number of age-, sex-, and ethnicity-matched controls were included in this study. Methylation-specific polymerase chain reaction was used to determine the p16 promoter methylation status. Single-nucleotide polymorphism at codon 72 of p53 gene was assessed by the polymerase chain reaction-restriction fragment length polymorphism method. Aberrant methylation of p16 gene was seen in 81% of esophageal cancer cases. Hypermethylation of p16 gene was not found in healthy controls. p53 Pro/Pro genotype was found to be a risk genotype in Northeast India compared with Arg/Pro and Arg/Arg. p53 variant/polymorphism was significantly associated with esophageal cancer risk in the study population under all three genetic models, namely,

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p16 hypermethylation: A biomarker for increased esophageal cancer susceptibility in high incidence region of North East India

Cited by 18 publications

References 32 publications

Incidence and survival differences in esophageal cancer among ethnic groups in the United States

Incidence and survival differences in esophageal cancer among ethnic groups in the United States

A multinational review: Oesophageal cancer in low to middle‑income countries (Review)

p16 gene silencing along with p53 single-nucleotide polymorphism and risk of esophageal cancer in Northeast India

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