p16 Expression: A marker of differentiation between childhood malignant melanomas and Spitz nevi

Dhaybi, Rola Al; Agoumi, Mehdi; Gagné, Isabelle; McCuaig, Catherine; Powell, Julie; Kokta, Victor

doi:10.1016/j.jaad.2010.07.031

Cited by 90 publications

(62 citation statements)

References 21 publications

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“…Most studies find p16 loss to be concerning for a borderline or malignant spitzoid neoplasm [8,9,[14][15][16]. However, a recent study found that 3/18 (17%) Spitz nevi also displayed p16 loss [15].…”

Section: Accepted Manuscriptmentioning

confidence: 99%

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Loss of p16 expression and copy number changes of CDKN2A in a spectrum of spitzoid melanocytic lesions

et al. 2016

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Section: Accepted Manuscriptmentioning

confidence: 99%

“…Germline mutation of CDKN2A is associated with familial melanoma [7]. Many studies have shown loss of p16 expression in conventional melanoma but not in benign melanocytic lesions [8][9][10].…”

Section: Introductionmentioning

confidence: 99%

Loss of p16 expression and copy number changes of CDKN2A in a spectrum of spitzoid melanocytic lesions

et al. 2016

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“…[149][150][151][152] However, heterogeneity within the same tumor has been reported, 153 and Mason et al 154 were not able to confirm those findings. The conflicting studies may partially be due to considerable variability in study design: inclusion of different types of melanocytic lesions, use of different p16 antibody clones, and definition of positive expression.…”

Section: Benign Versus Malignantmentioning

confidence: 91%

Immunohistochemistry in Dermatopathology

Ferringer

2015

Archives of Pathology &Amp; Laboratory Medicine

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Context.-Immunohistochemistry is not a diagnostic test but a highly valuable tool that requires interpretation within a context.Objective.-To review the current status and limitations of immunohistochemistry in dermatopathology.Data Sources.-English-language literature published between 1980 and 2014.Conclusions.-Although immunohistochemistry is rarely completely specific or sensitive, it is an important adjunctive technique in dermatopathology and can be helpful in a series of diagnostic dilemmas.

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“…This gene locus was lost in 50% of conventional melanomas, and patients with familial melanoma syndrome are associated with a homozygous loss of the CDKN2A gene. 12,15 The p16 protein, encoded by the gene CDKN2A on chromosome 9p, is critical to tumor suppression and has an important role in melanomas. 16,17 p16 Ink4a is a cyclin-dependent kinase inhibitor that blocks formation of the catalytically active CDK4/6-cyclin D complex, thereby preventing the phosphorylation of the retinoblastoma (Rb) gene and passage through the cell cycle's G1/S checkpoint (Figure 2a).…”

Section: Immunohistochemical Testsmentioning

confidence: 99%

A diagnostic algorithm for atypical spitzoid tumors: guidelines for immunohistochemical and molecular assessment

Cho‐Vega

2016

Modern Pathology

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Atypical spitzoid tumors are a morphologically diverse group of rare melanocytic lesions most frequently seen in children and young adults. As atypical spitzoid tumors bear striking resemblance to Spitz nevus and spitzoid melanomas clinically and histopathologically, it is crucial to determine its malignant potential and predict its clinical behavior. To date, many researchers have attempted to differentiate atypical spitzoid tumors from unequivocal melanomas based on morphological, immonohistochemical, and molecular diagnostic differences. A diagnostic algorithm is proposed here to assess the malignant potential of atypical spitzoid tumors by using a combination of immunohistochemical and cytogenetic/molecular tests. Together with classical morphological evaluation, this algorithm includes a set of immunohistochemistry assays (p16 Ink4a , a dual-color Ki67/MART-1, and HMB45), fluorescence in situ hybridization (FISH) with five probes (6p25, 8q24, 11q13, CEN9, and 9p21), and an array-based comparative genomic hybridization. This review discusses details of the algorithm, the rationale of each test used in the algorithm, and utility of this algorithm in routine dermatopathology practice. This algorithmic approach will provide a comprehensive diagnostic tool that complements conventional histological criteria and will significantly contribute to improve the diagnosis and prediction of the clinical behavior of atypical spitzoid tumors.

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p16 Expression: A marker of differentiation between childhood malignant melanomas and Spitz nevi

Cited by 90 publications

References 21 publications

Loss of p16 expression and copy number changes of CDKN2A in a spectrum of spitzoid melanocytic lesions

Loss of p16 expression and copy number changes of CDKN2A in a spectrum of spitzoid melanocytic lesions

Immunohistochemistry in Dermatopathology

A diagnostic algorithm for atypical spitzoid tumors: guidelines for immunohistochemical and molecular assessment

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