P155 Visualisation of Airway Nerves in Chronic Cough: Towards the Identification of the Human ‘Cough Receptor’

West, Peter; Canning, BJ; Hilton, EC; Khalid, Saif ur-Rahman; Holt, Kimberley; Abdulqawi, Rayid; Woodcock, A. S.; Smith, J. Lorrain

doi:10.1136/thoraxjnl-2012-202678.216

Thorax

2012

DOI: 10.1136/thoraxjnl-2012-202678.216

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P155 Visualisation of Airway Nerves in Chronic Cough: Towards the Identification of the Human ‘Cough Receptor’

Peter West

BJ Canning²,

EC Hilton

et al.

Abstract: Poster sessionsAbstract P154 Figure 1 VISUALISATION OF AIRWAY NERVES IN CHRONIC COUGH: TOWARDS THE IDENTIFICATION OF THE HUMAN 'COUGH RECEPTOR'

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“…Here, we describe the extensive assessment of the innervation present in mucosal biopsy tissue and for the first time, morphologic equivalents of the innervation described in other species. Some of these results have previously been reported in abstract form (19,20).…”

supporting

confidence: 50%

Morphologic Characterization of Nerves in Whole-Mount Airway Biopsies

West

Canning²,

Merlo‐Pich

et al. 2015

Am J Respir Crit Care Med

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Rationale: Neuroplasticity of bronchopulmonary afferent neurons that respond to mechanical and chemical stimuli may sensitize the cough reflex. Afferent drive in cough is carried by the vagus nerve, and vagal afferent nerve terminals have been well defined in animals. Yet, both unmyelinated C fibers and particularly the morphologically distinct, myelinated, nodose-derived mechanoreceptors described in animals are poorly characterized in humans. To date there are no distinctive molecular markers or detailed morphologies available for human bronchopulmonary afferent nerves.Objectives: Morphologic and neuromolecular characterization of the afferent nerves that are potentially involved in cough in humans.Methods: A whole-mount immunofluorescence approach, rarely used in human lung tissue, was used with antibodies specific to protein gene product 9.5 (PGP9.5) and, for the first time in human lung tissue, 200-kD neurofilament subunit. Measurements and Main Results:We have developed a robust technique to visualize fibers consistent with autonomic and C fibers and pulmonary neuroendocrine cells. A group of morphologically distinct, 200-kD neurofilament-immunopositive myelinated afferent fibers, a subpopulation of which did not express PGP9.5, was also identified.Conclusions: PGP9.5-immunonegative nerves are strikingly similar to myelinated airway afferents, the cough receptor, and smooth muscle-associated airway receptors described in rodents. These have never been described in humans. Full description of human airway nerves is critical to the translation of animal studies to the clinical setting.

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supporting

confidence: 50%

Morphologic Characterization of Nerves in Whole-Mount Airway Biopsies

West

Canning²,

Merlo‐Pich

et al. 2015

Am J Respir Crit Care Med

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P155 Visualisation of Airway Nerves in Chronic Cough: Towards the Identification of the Human ‘Cough Receptor’

Abstract: Poster sessionsAbstract P154 Figure 1 VISUALISATION OF AIRWAY NERVES IN CHRONIC COUGH: TOWARDS THE IDENTIFICATION OF THE HUMAN 'COUGH RECEPTOR'

Cited by 1 publication

References 0 publications

Morphologic Characterization of Nerves in Whole-Mount Airway Biopsies

Morphologic Characterization of Nerves in Whole-Mount Airway Biopsies

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