P152 Prediction of Death or Heart Failure-related Hospitalizations by Cardio-ankle Vascular Index (CAVI) and CAVI0

Abstract

Background: Arterial stiffness as measured by carotid-femoral pulse wave velocity (PWV) has been shown to predict cardiovascular events [1]. However, PWV is blood pressure (BP) dependent [2,3] leading to the development of cardio-ankle vascular index (CAVI) as a more blood pressure-independent index [4] that also shows predictive ability in Asian populations [5]. Recently, CAVI was further refined into CAVI 0 [6], removing residual acute blood pressure dependence [7]. The present study aims to assess risk prediction by CAVI and CAVI 0 in a US population.

Five years of cardio-ankle vascular index (CAVI) and CAVI0: how close are we to a pressure-independent index of arterial stiffness?

“…Similar results obtained using the two metrics. Spronck [41] Clinical longitudinal 156 Showed that both right CAVI and right CAVI 0 but not left CAVI and left CAVI 0 , predicted heart-failure related end points in a population of 156 individuals. Possible body-side difference in the prediction power of CAVI and CAVI 0 .…”

“…Performing analysis using CAVI 0 yielded similar results. We investigated the ability of R-CAVI, L-CAVI, R-CAVI 0 and L-CAVI 0 of predicting heart failure-related endpoints and found that only R-CAVI and R-CAVI 0 had predictive power [41]. Finally, the VaSera trial [42,43] is a double-blinded, parallel, randomized controlled intervention trial evaluating the effect of four interventions (spironolactone, doxazosin, dietary nitrate beetroot juice, and nitrate-free beetroot juice) on arterial stiffness.…”