P15.06: Distinct FOXP3 Gene Expression in the Peripheral Blood And Inside Renal Allografts Is Associated With Use of MTOR Inhibitors and Extended Criteria Kidney Donor
Abstract:Background: Trafficking of regulatory T cells (Tregs) modulate inflammatory response after kidney transplantation. There is scarce information on whether circulating and intragraft Tregs are similarly affected by immunosuppressive drugs (ISD) and by the type of deceased kidney donor.Objectives: 1-to study the simultaneous gene and protein expression of the FOXP3 (forkhead-winged helix transcription factor) in the peripheral blood (PB) and within renal allografts; 2-to correlate FOXP3 expression with the immuno… Show more
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