P1464Adoption of feedback to validate a machine learning model for single lead STEMI detection

Abstract

Background We have explored the performance of a single lead EKG with Artificial Intelligence (AI) based algorithms in STEMI diagnosis, thus far lead V2 has yielded the best results. Anticipating the performance of the LUMENGT-AI model, we designed a feedback strategy with healthcare centers to expand the validation of our work. Purpose To create a pragmatic alternative to the existing gold standard, a 12-lead EKG, for STEMI diagnosis. Methods An observational, retrospective, case-control study. Sample: 2,543 exclusively STEMI (anterior, inferior and lateral wall) diagnosis, EKG records. Feedback: From healthcare centers, confirming STEMI diagnosis and location, was obtained (thrombolysis, primary Percutaneous Coronary Intervention (PCI), pharmaco invasive therapy or coronary artery bypass surgery). Records excluded other patient and medical information. Sample was derived from the private International Telemedical Systems (ITMS) database. LUMENGT-AI Algorithm was employed. Preprocessing: detection of QRS complexes using the wavelet system, segmentation of each EKG into individual heartbeats (53,667 total beats) with fixed window of 0.4s to the left and 0.9s to the right of main QRS; Classification: A 1-D convolutional neural network was implemented; “STEMI” and “Not-STEMI” classes were considered for each heartbeat per lead; individual probabilities were aggregated to generate the final label for each record. Training & Testing: 90% and 10% of the sample were used, respectively. Experiments: Intel PC i7 8750H processor at 2.21GHz, 16GB RAM, Windows 10 OS with NVidia GTX 1070 GPU, 8GB RAM. Results V2 was the most precise lead with an Accuracy of 93.6%, a Sensitivity of 89%, and a Specificity of 94.7%. Conclusions The strategic adoption of feedback from healthcare centers provided strong validation of our model. The results of AI-augmented, single lead EKG are encouraging. We anticipate that this approach will become a promising methodology in STEMI detection.