P135 Impact d’une prise d’eau accrue dans la formation d’adduits à l’ADN et la mutagénicité urinaire chez les fumeurs : Une étude clinique contrôlée randomisée

Buendia, I.; Richardot, P.; Picard, Pascaline; Talaska, Glenn; Méo, Michel De; Friedlander, Gérard

doi:10.1016/s0007-9960(13)70493-0

Cited by 1 publication

(2 citation statements)

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“…On the following 3 days, intake volumes were reversed between groups (LD: increased intake to 2.5 L/d; HD: intake restricted to 1.0 L/d). Five consecutive 24-h urine samples were collected during the inpatient trial c Study C [ 26 ]. Habitual low-volume drinkers were assigned either to a control group or to a 7-week water intake intervention designed to increase TFI (+1.5 L/d plain water on top of their normal daily fluid intake).…”

Section: Methodsmentioning

confidence: 99%

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Urine colour change as an indicator of change in daily water intake: a quantitative analysis

et al. 2015

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PurposeUrine colour (UCol) is simple to measure, differs between low-volume and high-volume drinkers, and is responsive to changes in daily total fluid intake (TFI). However, to date, no study has quantified the relationship between a change in TFI and the resultant change in UCol. This analysis aimed to determine the change in TFI needed to adjust 24-h UCol by 2 shades on an 8-colour scale, and to evaluate whether starting UCol altered the relationship between the change in TFI and change in UCol.MethodsWe performed a pooled analysis on data from 238 healthy American and European adults (50 % male; age, 28 (sd 6) years; BMI 22.9 (sd 2.6) kg/m2), and evaluated the change in TFI, urine volume (UVol), and specific gravity (USG) associated with a change in UCol of 2 shades.ResultsThe mean [95 % CI] change in TFI and UVol associated with a decrease in UCol by 2 shades (lighter) was 1110 [914;1306] and 1011 [851;1172] mL/day, respectively, while increasing UCol by 2 shades (darker) required a reduction in TFI and UVol of −1114 [−885;−1343] and −977 [−787;−1166] mL/day. The change in UCol was accompanied by changes in USG (lighter urine: −.008 [−.007;−.010]; darker urine: +.008 [.006;.009]). Starting UCol did not significantly impact the TFI change required to modify UCol by 2 shades.ConclusionsOur results suggest a quantifiable relationship between a change in daily TFI and the resultant change in UCol, providing individuals with a practical means for evaluating and adjusting hydration behaviours.

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Section: Methodsmentioning

confidence: 99%

“…c Study C [ 26 ]. Habitual low-volume drinkers were assigned either to a control group or to a 7-week water intake intervention designed to increase TFI (+1.5 L/d plain water on top of their normal daily fluid intake).…”

Section: Methodsmentioning

confidence: 99%