Abstract:Aplastic anemia(AA), regarded as pancytopenia and bone marrow(BM) failure, is thought to be primarily caused by a profound deficit in hematopoietic stem and progenitor cells and abnormally activated immune cells. Recently, increasing evidence suggested that alterations in the BM microenvironment contribute to the process of AA. Endothelial cell(EC), which is a key component of BM microenvironment, plays a crucial role in supporting hematopoiesis and regulating immunity. Our previous studies (Blood2016, Blood20… Show more
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