P133 Fecal calprotectin and CRP as biomarkers of endoscopic activity in Crohn's disease: A meta-study

Associations Among Mucosal and Transmural Healing and Fecal Level of Calprotectin in Children With Crohn’s Disease

“…34,35 Some studies have examined combined cutoffs of calprotectin and CRP for predicting mucosal healing. Bondjemah et al 36 showed that in adult active CD, calprotectin of 200 mg/g or CRP mg/L can predict CDEIS 6 with 83% sensitivity and 71% specificity. When the study examined 355 patients in clinical remission, the combination of CRP 10 mg/L and calprotectin 200 mg/g predicted CDEIS 3 with 78% sensitivity and 58% specificity.…”

Role of endoscopy, cross-sectional imaging and biomarkers in Crohn's disease monitoring

“…CRP and faecal calprotectin may thus be best used as first-line tools to decide whether or not there is a need for endoscopic or cross-sectional imaging reassessment. In this perspective, an interesting meta-study was recently performed, analysing the data of six studies that included more than 550 patients and provided blood CRP and faecal calprotectin levels together with endoscopic scores of severity 57. In patients with symptoms (CDAI >220), the sensitivity of CRP ≤5 mg/l or calprotectin ≤200 μg/g to anticipate a CDEIS ≤6 was 83% and the specificity 71%.…”

“…It is thus again as first-line tests and in combination with endoscopy and/or cross-sectional imaging that these biomarkers may be best used. The previously mentioned meta-study also addressed this question 57. When patients with inactive disease (CDAI ≤150) are considered, the sensitivity of the association of CRP ≤10 mg/l and calprotectin ≤200 μg/g to predict a CDEIS ≤3 was 78% and the specificity 58%.…”

New Trends in Inflammatory Bowel Disease

“… 36 A recent meta-study analysing data from six studies (551 CD patients) found that in patients with symptoms (CDAI > 220), CRP ≤ 5 mg/l or calprotectin ≤ 200 μg/g predicted a CDEIS ≤ 6 with a sensitivity and specificity of 83% and 71%, respectively. 46 Therefore with the use of appropriate threshold levels, these biomarkers could help to make decisions about the ideal timing of endoscopy. 41 …”