P1296 Molecular characterisation of methicillin-resistant Staphylococcus aureus in South Africa

Oosthuysen, Wilhelm F.; Dusé, Adriano; Marais, Elsé

doi:10.1016/s0924-8579(07)71136-6

Cited by 2 publications

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“…The distribution of PFGE clusters, SCC mec types and STs did not differ between the HA‐MRSA and putative CA‐MRSA, and the pvl gene was not detected in any of the isolates. This was consistent with previous studies in which this gene was either infrequently or not detected in South African MRSA strains [10,20,21].…”

Section: Discussionsupporting

confidence: 93%

The dominant methicillin‐resistant Staphylococcus aureus clone from hospitals in Cape Town has an unusual genotype: ST612

Rensburg

Madikane

Whitelaw

et al. 2011

Clinical Microbiology and Infection

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There is currently limited information available on the molecular epidemiology of methicillin-resistant Staphylococcus aureus (MRSA) in South Africa. A molecular characterization of 100 MRSA from five hospitals in Cape Town was carried out in this study. The strains were separated into six clusters by pulsed-field gel electrophoresis, indicating transmission of MRSA between local hospitals. None of the strains carried the Panton-Valentine Leukocidin gene. SCCmec typing, multilocus sequence typing and spa typing were used to further characterize the MRSA. Three clones corresponded to frequently described pandemic clones: ST239-MRSA-III, ST36-MRSA-II and ST5-MRSA-I. ST239-MRSA-III and ST36-MRSA-II were minor clones and collectively accounted for 16% of the isolates. ST5-MRSA-I was the second-most prevalent clone and accounted for 37% of the isolates. The dominant local clone was the infrequently described ST612-MRSA-IV (44% of isolates), which has only been described in South Africa and Australia.

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Section: Discussionsupporting

confidence: 93%