p120‐catenin is required for regulating epidermal proliferation, differentiation, and barrier function

Abstract

p120-catenin (p120) is an important regulator in the function and stability of E-cadherin. However, the role of p120 in the epidermis is unclear. Previous studies have shown that globally knockout of p120 caused increased epidermal proliferation but little changes in epidermal differentiation and permeability. In the present study, we generated a conditional knockout mouse model and examined epidermal proliferation, differentiation and permeability. The results showed that conditional knockout of p120 in the epidermis caused not only increased epidermal proliferation but also decreased epidermal differentiation and increased permeability. These data suggest that p120 is required for suppressing epidermal proliferation, promoting epidermal differentiation and maintaining permeability barrier function of the epidermis.

Effects of nicorandil on p120 expression in the spinal cord and dorsal root ganglion of rats with chronic postsurgical pain

“…a previous study examined the role of cx43 in chronic pain (28); however, to the best of our knowledge, the relationship between p120 and chronic pain remains to be elucidated. p120 is known to exhibit a role in adhesion among cells and in signal transduction in cells (29)(30)(31)(32). it has also been reported that p120 protects against post-traumatic inflammation by regulating the adherens and tight gap junctions (33,34).…”

p120‐catenin suppresses proliferation and tumor growth of oral squamous cell carcinoma via inhibiting nuclear phospholipase C‐γ1 signaling

“…Therefore, understanding the mechanism of OSCC development and designing novel therapeutic strategies are desperately needed. p120-catenin (p120) functions as a stabilizer of the E-cadherin/ catenin complex and plays an important role in cell-cell adhesion as well as intracellular signaling (Davis, Ireton, & Reynolds, 2003;Fukumoto, Shintani, Reynolds, Johnson, & Wheelock, 2008;Ireton et al, 2002;Xiao et al, 2003;Xie & Bikle, 2007;Xie et al, 2017;Xie, Tang, Man, Shrestha, & Bikle, 2018). It has been shown that decreased plasma membrane expression of p120 correlates with the occurrence, development, and prognosis of various types of cancers, such as cancers of the prostate, esophagus, bladder, and breast (Chen et al, 2015;Kallakury, Sheehan, & Ross, 2001;Silva Neto et al, 2008;Talvinen et al, 2010;Wijnhoven, Pignatelli, Dinjens, & Tilanus, 2005).…”