P116. Nitrite augments post-ischemic vascular function—A putative therapeutic preconditioning mimetic

Berg, Adam M.; Tremonti, Carole K.; Vasquez, Veronica M.; Shiva, Sruti; Gladwin, Mark T.; Sack, Michael N.

doi:10.1016/j.niox.2006.04.182

Cited by 1 publication

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“…Table V shows that the oxygen levels in working muscle fall to rather low values. More recently, forearm plethysmographic studies have shown that the administration of nitrite prior to ischemic stress improves the post-ischemic blood flow in the affected area (98). …”

Section: Nitrite Protects Against Ischemia/reperfusion Injury: Earmentioning

confidence: 99%

Nitrite as regulator of hypoxic signaling in mammalian physiology

Faassen

Bahrami

Feelisch

et al. 2009

Medicinal Research Reviews

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In this review we consider the physiological effects of endogenous and pharmacological levels of nitrite under conditions of hypoxia. In humans, the nitrite anion has long been considered as metastable intermediate in the oxidation of nitric oxide radicals to the stable metabolite nitrate. This oxidation cascade was thought to be irreversible under physiological conditions. However, a growing body of experimental observations attests that the presence of endogenous nitrite regulates a number of signaling events along the physiological and pathophysiological oxygen gradient. Hypoxic signaling events include vasodilation, modulation of mitochondrial respiration, and cytoprotection following ischemic insult. These phenomena are attributed to the reduction of nitrite anions to nitric oxide if local oxygen levels in tissues decrease. Recent research identified a growing list of enzymatic and non-enzymatic pathways for this endogenous reduction of nitrite. Additional direct signaling events not involving free nitric oxide are proposed. We here discuss the mechanisms and properties of these various pathways and the role played by the local concentration of free oxygen in the affected tissue.

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Section: Nitrite Protects Against Ischemia/reperfusion Injury: Earmentioning

confidence: 99%